Phenotypic characterization of GPR120-expressing cells in the interstitial tissue of pancreas

Zhao, Yufeng, Zha, Dingjun, Wang, Li, Qiao, Li, Lu, Lianjun, Mei, Lin, Chen, Chen and Qiu, Jianhua (2013) Phenotypic characterization of GPR120-expressing cells in the interstitial tissue of pancreas. Tissue and Cell, 45 6: 421-427. doi:10.1016/j.tice.2013.07.005


Author Zhao, Yufeng
Zha, Dingjun
Wang, Li
Qiao, Li
Lu, Lianjun
Mei, Lin
Chen, Chen
Qiu, Jianhua
Title Phenotypic characterization of GPR120-expressing cells in the interstitial tissue of pancreas
Journal name Tissue and Cell   Check publisher's open access policy
ISSN 0040-8166
1532-3072
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.tice.2013.07.005
Volume 45
Issue 6
Start page 421
End page 427
Total pages 7
Place of publication London, United Kingdom
Publisher Churchill Livingstone
Language eng
Subject 1307 Cell Biology
1309 Developmental Biology
Abstract GPR120 functions as a plasma membrane receptor for unsaturated long-chain free fatty acids and involves in GLP-1 secretion, adipogenesis and the control of energy balance. Pancreas is the key organ in fuel and energy metabolism. Here GPR120 expression in human and rat pancreas was observed by RT-PCR, and the distribution and phenotypes of GPR120-positive cells in human and rat pancreas were shown by immunohistochemical staining. GPR120 mRNA expression was found in human and rat pancreas. GPR120-positive cells were scattered mainly in the interstitial tissues of human and rat pancreas, and they were not co-localized with nestin, vimentin, alpha-SMA and glucagon, respectively. However, GPR120 was distributed on the cells positively stained by CD68, the specific marker of macrophages, and on the cells positive stained by CD34 and CD117, the markers of interstitial cells. In conclusion, this study demonstrates the expression of GPR120 in pancreas and shows the distribution of GPR120 in human and rat pancreas.
Keyword CD117
CD34
CD68
GPR120
Pancreas
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Biomedical Sciences Publications
 
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