Neutrophils-A key component of ischemia-reperfusion injury

Schofield, Zoe Victoria, Woodruff, Trent Martin, Halai, Reena, Wu, Mike Chia-Lun and Cooper, Matthew Allister (2013) Neutrophils-A key component of ischemia-reperfusion injury. Shock, 40 6: 463-470. doi:10.1097/SHK.0000000000000044

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Author Schofield, Zoe Victoria
Woodruff, Trent Martin
Halai, Reena
Wu, Mike Chia-Lun
Cooper, Matthew Allister
Title Neutrophils-A key component of ischemia-reperfusion injury
Journal name Shock   Check publisher's open access policy
ISSN 1073-2322
Publication date 2013-01-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1097/SHK.0000000000000044
Open Access Status File (Author Post-print)
Volume 40
Issue 6
Start page 463
End page 470
Total pages 8
Place of publication Baltimore, MD United States
Publisher Lippincott Williams and Wilkins
Language eng
Subject 2711 Emergency Medicine
2706 Critical Care and Intensive Care Medicine
Abstract Ischemia-reperfusion injury (IRI) is a common occurrence following myocardial infarction, transplantation, stroke, and trauma that can lead to multiple organ failure, which remains the foremost cause of death in critically ill patients. Current therapeutic strategies for IRI are mainly palliative, and there is an urgent requirement for a therapeutic that could prevent or reverse tissue damage caused by IRI. Neutrophils are the primary responders following ischemia and reperfusion and represent important components in the protracted inflammatory response and severity associated with IRI. Experimental studies demonstrate neutrophil infiltration at the site of ischemia and show that inducing neutropenia can protect organs from IRI. In this review, we highlight the mechanisms involved in neutrophil recruitment, activation, and adherence and how this contributes to disease severity in IRI. Inhibiting neutrophil mobilization, tissue recruitment, and ultimately neutrophil-associated activation of local and systemic inflammatory responses may have therapeutic potential in the amelioration of local and remote tissue damage following IRI. Copyright
Keyword Cytokines
Multiple organ failure
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID AF51105
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Biomedical Sciences Publications
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 52 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 10 Dec 2013, 10:23:38 EST by System User on behalf of Institute for Molecular Bioscience