F-18-florbetaben A beta imaging in mild cognitive impairment

Ong, Kevin, Villemagne, Victor L., Bahar-Fuchs, Alex, Lamb, Fiona, Chetelat, Gael, Raniga, Parnesh, Mulligan, Rachel S., Salvado, Olivier, Putz, Barbara, Roth, Katrin, Masters, Colin L., Reininger, Cornelia B. and Rowe, Christopher C. (2013) F-18-florbetaben A beta imaging in mild cognitive impairment. Alzheimers Research & Therapy, 5 1: . doi:10.1186/alzrt158


Author Ong, Kevin
Villemagne, Victor L.
Bahar-Fuchs, Alex
Lamb, Fiona
Chetelat, Gael
Raniga, Parnesh
Mulligan, Rachel S.
Salvado, Olivier
Putz, Barbara
Roth, Katrin
Masters, Colin L.
Reininger, Cornelia B.
Rowe, Christopher C.
Title F-18-florbetaben A beta imaging in mild cognitive impairment
Journal name Alzheimers Research & Therapy   Check publisher's open access policy
ISSN 1758-9193
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1186/alzrt158
Open Access Status DOI
Volume 5
Issue 1
Total pages 11
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Formatted abstract
Introduction
18F-florbetaben and positron emission tomography were used to examine the relationships between β-amyloid (Aβ) deposition, cognition, hippocampal volume, and white matter hyperintensities in mild cognitive impairment (MCI).
Methods
Forty-five MCI participants were evaluated. A neocortical standardized uptake value ratio threshold ≥ 1.45 was used to discriminate high from low Aβ burden. Correlations were adjusted for age, gender and years of education.
Results
High Aβ burden was found in 53% of MCI. Regression analyses showed standardized uptake value ratio (r = -0.51, P = 0.0015) and hippocampal volume (r = 0.60, P = 0.024) both contributing to episodic memory impairment in independent fashion. White matter hyperintensities correlated with nonmemory cognition, and this correlation was particularly associated with Aβ burden.
Conclusion
Higher Aβ deposition in MCI is associated with more severe memory impairment and is contributing to early amnestic symptoms independent of hippocampal atrophy.
Keyword Alzheimers Association Workgroups
Neurofibrillary Tangles
Amyloid Deposition
White-Matter
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 509166
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Medicine Publications
 
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