Melanoma's connections to the tumour microenvironment

Brandner, Johanna M. and Haass, Nikolas K. (2013) Melanoma's connections to the tumour microenvironment. Pathology, 45 5: 443-452. doi:10.1097/PAT.0b013e328363b3bd

Author Brandner, Johanna M.
Haass, Nikolas K.
Title Melanoma's connections to the tumour microenvironment
Journal name Pathology   Check publisher's open access policy
ISSN 0031-3025
Publication date 2013-01-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1097/PAT.0b013e328363b3bd
Open Access Status
Volume 45
Issue 5
Start page 443
End page 452
Total pages 10
Place of publication London, United Kingdom
Publisher Lippincott Williams & Wilkins, Ltd.
Language eng
Subject 2734 Pathology and Forensic Medicine
Abstract Melanoma cells interact with and depend on seemingly normal cells in their tumour microenvironment to allow the acquisition of the hallmarks of solid cancer. In general, there are three types of interaction of melanoma cells with their microenvironment. First, there is bilateral communication between melanoma cells and the stroma, which includes fibroblasts, endothelial cells, immune cells, soluble molecules, and the extracellular matrix. Second, while under normal conditions keratinocytes control localisation and proliferative behaviour of melanocytes in the epidermis, once this balance is disturbed and a melanoma has developed, melanoma cells may take over the control of their epidermal tumour microenvironment. Finally, there are subcompartments within tumours with different microenvironmental milieu defined by their access to oxygen and nutrients. Therefore, different melanoma cells within a tumour face different microenvironments. Interactions between melanoma cells among each other and with the cell types in their microenvironment happen through endocrine and paracrine communication and/or through direct contact via cell-cell and cell-matrix adhesion, and gap junctional intercellular communication (GJIC). Connexins have been identified as key molecules for direct cell-cell communication and are also thought to be important for the release of signalling molecules from cells to the microenvironment. In this review we provide an update of the alterations in cell-cell communication in melanoma and the tumour microenvironment associated with melanoma development and progression.
Keyword Cell communication
Gap junctions
Tumour microenvironment
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID RG 09-08
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 29 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 31 times in Scopus Article | Citations
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