Koala retroviruses: Characterization and impact on the life of koalas

Denner, Joachim and Young, Paul R. (2013) Koala retroviruses: Characterization and impact on the life of koalas. Retrovirology, 10 1: 108.1-108.7. doi:10.1186/1742-4690-10-108


Author Denner, Joachim
Young, Paul R.
Title Koala retroviruses: Characterization and impact on the life of koalas
Journal name Retrovirology   Check publisher's open access policy
ISSN 1742-4690
Publication date 2013-10-23
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/1742-4690-10-108
Open Access Status DOI
Volume 10
Issue 1
Start page 108.1
End page 108.7
Total pages 7
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Formatted abstract
Koala retroviruses (KoRV) have been isolated from wild and captive koalas in Australia as well as from koala populations held in zoos in other countries. They are members of the genus Gammaretrovirus, are most closely related to gibbon ape leukemia virus (GaLV), feline leukemia virus (FeLV) and porcine endogenous retrovirus (PERV) and are likely the result of a relatively recent trans-species transmission from rodents or bats. The first KoRV to be isolated, KoRV-A, is widely distributed in the koala population in both integrated endogenous and infectious exogenous forms with evidence from museum specimens older than 150 years, indicating a relatively long engagement with the koala population. More recently, additional subtypes of KoRV that are not endogenized have been identified based on sequence differences and host cell receptor specificity (KoRV-B and KoRV-J). A specific association with fatal lymphoma and leukemia has been recently suggested for KoRV-B. In addition, it has been proposed that the high viral loads found in many animals may lead to immunomodulation resulting in a higher incidence of diseases such as chlamydiosis. Although the molecular basis of this immunomodulation is still unclear, purified KoRV particles and a peptide corresponding to a highly conserved domain in the envelope protein have been shown to modulate cytokine expression in vitro, similar to that induced by other gammaretroviruses. While much is still to be learned, KoRV induced lymphoma/leukemia and opportunistic disease arising as a consequence of immunomodulation are likely to play an important role in the stability of koala populations both in the wild and in captivity.
Keyword Gammaretroviruses
Immunodeficiency
Koala retrovirus
Lymphoma
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Chemistry and Molecular Biosciences
 
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