Synergy effects of HbA1c and variants of APOE and BDNFVal66Met explains individual differences in memory performance

Persson, N., Lavebratt, C. and Wahlin, T. (2013) Synergy effects of HbA1c and variants of APOE and BDNFVal66Met explains individual differences in memory performance. Neurobiology of Learning and Memory, 106 274-282. doi:10.1016/j.nlm.2013.08.017


Author Persson, N.
Lavebratt, C.
Wahlin, T.
Title Synergy effects of HbA1c and variants of APOE and BDNFVal66Met explains individual differences in memory performance
Journal name Neurobiology of Learning and Memory   Check publisher's open access policy
ISSN 1074-7427
1095-9564
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.nlm.2013.08.017
Open Access Status
Volume 106
Start page 274
End page 282
Total pages 9
Place of publication Maryland Heights, MO United States
Publisher Academic Press
Language eng
Subject 2802 Behavioral Neuroscience
2805 Cognitive Neuroscience
3205 Experimental and Cognitive Psychology
Abstract We aimed at exploring if synergy effects of Brain-Derived Neurotrophic Factor (BDNF) Val66Met, Apolipoprotein E (APOE) and HbA1c (glycated haemoglobin) could explain individual differences in memory performance over 10years in a population based sample of nondemented adults (N=888, 35-85years at baseline). Episodic memory was affected by such agents, wheras semantic memory was spared. Both age and HbA1c were associated with episodic memory decline. BDNF66Met carriers with higher HbA1c levels evidenced slope decline in episodic recall. We found support for joint effects of BDNFVal66Met×APOE×HbA1c and BDNFVal66Met×APOE×age on rates of episodic memory change over ten years, after controlling for age, sex, education and cardiovascular diseases. We conclude that variants of genetic polymorphisms act in synergy with long-term blood glucose control in shaping patterns of cognitive aging.
Keyword Aging
Episodic memory
Epistasis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
 
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