The physical anthropometry, lifestyle habits and blood pressure of people presenting with a first clinical demyelinating event compared to controls: the Ausimmune study

Ponsonby, Anne-Louise, Lucas, Robyn M., Dear, Keith, van der Mei, Ingrid, Taylor, Bruce, Chapman, Caron, Coulthard, Alan, Dwyer, Terence, Kilpatrick, Trevor J., McMichael, Anthony J., Pender, Michael P., Valery, Patricia C. and Williams, David (2013) The physical anthropometry, lifestyle habits and blood pressure of people presenting with a first clinical demyelinating event compared to controls: the Ausimmune study. Multiple Sclerosis, 19 13: 1717-1725. doi:10.1177/1352458513483887


Author Ponsonby, Anne-Louise
Lucas, Robyn M.
Dear, Keith
van der Mei, Ingrid
Taylor, Bruce
Chapman, Caron
Coulthard, Alan
Dwyer, Terence
Kilpatrick, Trevor J.
McMichael, Anthony J.
Pender, Michael P.
Valery, Patricia C.
Williams, David
Title The physical anthropometry, lifestyle habits and blood pressure of people presenting with a first clinical demyelinating event compared to controls: the Ausimmune study
Journal name Multiple Sclerosis   Check publisher's open access policy
ISSN 1352-4585
1477-0970
Publication date 2013-11-01
Year available 2013
Sub-type Article (original research)
DOI 10.1177/1352458513483887
Volume 19
Issue 13
Start page 1717
End page 1725
Total pages 9
Place of publication London, United Kingdom
Publisher Sage
Language eng
Formatted abstract
Introduction: Lifestyle factors prior to a first clinical demyelinating event (FCD), a disorder often preceding the development of clinically definite multiple sclerosis (MS), have not previously been examined in detail. Past tobacco smoking has been consistently associated with MS.

Methods: This was a multicentre incident case-control study. Cases (n = 282) were aged 18-59 years with an FCD and resident within one of four Australian centres (from latitudes 27°S to 43°S), from 1 November 2003 to 31 December 2006. Controls (n = 558) were matched to cases on age, sex and study region, without CNS demyelination. Exposures measured included current and past tobacco and marijuana, alcohol and beverage use, physical activity patterns, blood pressure and physical anthropometry.

Results: A history of smoking ever was associated with FCD risk (AOR 1.89 (95%CL 1.82, 3.52)). Marijuana use was not associated with FCD risk after adjusting for confounders such as smoking ever but the estimates were imprecise because of a low prevalence of use. Alcohol consumption was common and not associated with FCD risk. No casecontrol differences in blood pressure or physical anthropometry were observed.

Conclusions: Past tobacco smoking was positively associated with a risk of FCD but most other lifestyle factors were not. Prevention efforts against type 2 diabetes and cardiovascular disease by increasing physical activity and reducing obesity are unlikely to alter MS incidence, and more targeted campaigns will be required.
Keyword Demyelination
Lifestyle
Marijuana
Multiple sclerosis
Obesity
Tobacco
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
 
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