A pilot study: the importance of inter-individual differences in inorganic arsenic metabolism for birth weight outcome

Gelmann, Elyssa R., Gurzau, Eugen, Gurzau, Anca, Goessler, Walter, Kunrath, Julie, Yeckel, Catherine W. and McCarty, Kathleen M. (2013) A pilot study: the importance of inter-individual differences in inorganic arsenic metabolism for birth weight outcome. Environmental Toxicology and Pharmacology, 36 3: 1266-1275. doi:10.1016/j.etap.2013.10.006


Author Gelmann, Elyssa R.
Gurzau, Eugen
Gurzau, Anca
Goessler, Walter
Kunrath, Julie
Yeckel, Catherine W.
McCarty, Kathleen M.
Title A pilot study: the importance of inter-individual differences in inorganic arsenic metabolism for birth weight outcome
Journal name Environmental Toxicology and Pharmacology   Check publisher's open access policy
ISSN 1382-6689
1872-7077
Publication date 2013-11-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.etap.2013.10.006
Volume 36
Issue 3
Start page 1266
End page 1275
Total pages 10
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Formatted abstract
Inorganic arsenic (iAs) exposure is detrimental to birth outcome. We lack information regarding the potential for iAs metabolism to affect fetal growth. Our pilot study evaluated postpartum Romanian women with known birth weight outcome for differences in iAs metabolism. Subjects were chronically exposed to low-to-moderate drinking water iAs. We analyzed well water, arsenic metabolites in urine, and toenail arsenic. Urine iAs and metabolites, toenail iAs, and secondary methylation efficiency increased as an effect of exposure (p< 0.001). Urine iAs and metabolites showed a significant interaction effect between exposure and birth weight. Moderately exposed women with low compared to normal birth weight outcome had greater metabolite excretion (p< 0.03); 67% with low compared to 10% with normal birth weight outcome presented urine iAs >9. μg/L (p= 0.019). Metabolic partitioning of iAs toward excretion may impair fetal growth. Prospective studies on iAs excretion before and during pregnancy may provide a biomarker for poor fetal growth risk.
Keyword Arsenic
Biomarker
Birth weight
Methylation ratio
Romania
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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