Luminal Mitosis Drives Epithelial Cell Dispersal within the Branching Ureteric Bud

Packard, Adam, Georgas, Kylie, Michos, Odysse, Riccio, Paul, Cebrian, Cristina, Combes, Alexander N., Ju, Adler, Ferrer-Vaquer, Anna, Hadjantonakis, Anna-Katerina, Zong, Hui, Little, Melissa H. and Costantini, Frank (2013) Luminal Mitosis Drives Epithelial Cell Dispersal within the Branching Ureteric Bud. Developmental Cell, 27 3: 319-330. doi:10.1016/j.devcel.2013.09.001

Author Packard, Adam
Georgas, Kylie
Michos, Odysse
Riccio, Paul
Cebrian, Cristina
Combes, Alexander N.
Ju, Adler
Ferrer-Vaquer, Anna
Hadjantonakis, Anna-Katerina
Zong, Hui
Little, Melissa H.
Costantini, Frank
Title Luminal Mitosis Drives Epithelial Cell Dispersal within the Branching Ureteric Bud
Journal name Developmental Cell   Check publisher's open access policy
ISSN 1534-5807
Publication date 2013-11-11
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.devcel.2013.09.001
Open Access Status Not yet assessed
Volume 27
Issue 3
Start page 319
End page 330
Total pages 12
Place of publication Cambridge, MA United States
Publisher Cell Press
Language eng
Subject 1309 Developmental Biology
Abstract The ureteric bud is an epithelial tube that undergoes branching morphogenesis to form the renal collecting system. Although development of a normal kidney depends on proper ureteric bud morphogenesis, the cellular events underlying this process remain obscure. Here, we used time-lapse microscopy together with several genetic labeling methods to observe ureteric bud cell behaviors in developing mouse kidneys. We observed an unexpected cell behavior in the branching tips of the ureteric bud, which we term "mitosis-associated cell dispersal." Premitotic ureteric tip cells delaminate from the epithelium and divide within the lumen; although one daughter cell retains a basal process, allowing it to reinsert into the epithelium at the site of origin, the other daughter cell reinserts at a position one to three cell diameters away. Given the high rate of cell division in ureteric tips, this cellular behavior causes extensive epithelial cell rearrangements that may contribute to renal branching morphogenesis.
Keyword Cell Biology
Developmental Biology
Cell Biology
Developmental Biology
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 5R01DK083289
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 40 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 43 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Tue, 03 Dec 2013, 10:45:22 EST by System User on behalf of Institute for Molecular Bioscience