Building the mammalian testis: origins, differentiation, and assembly of the component cell populations

Svingen, Terje and Koopman, Peter (2013) Building the mammalian testis: origins, differentiation, and assembly of the component cell populations. Genes and Development, 27 22: 2409-2426. doi:10.1101/gad.228080.113


Author Svingen, Terje
Koopman, Peter
Title Building the mammalian testis: origins, differentiation, and assembly of the component cell populations
Journal name Genes and Development   Check publisher's open access policy
ISSN 0890-9369
1549-5477
Publication date 2013-11-15
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1101/gad.228080.113
Open Access Status DOI
Volume 27
Issue 22
Start page 2409
End page 2426
Total pages 18
Place of publication Woodbury, NY, United States
Publisher Cold Spring Harbor Laboratory Press
Language eng
Formatted abstract
Development of testes in the mammalian embryo requires the formation and assembly of several cell types that allow these organs to achieve their roles in male reproduction and endocrine regulation. Testis development is unusual in that several cell types such as Sertoli, Leydig, and spermatogonial cells arise from bipotential precursors present in the precursor tissue, the genital ridge. These cell types do not differentiate independently but depend on signals from Sertoli cells that differentiate under the influence of transcription factors SRY and SOX9. While these steps are becoming better understood, the origins and roles of many testicular cell types and structures-including peritubular myoid cells, the tunica albuginea, the arterial and venous blood vasculature, lymphatic vessels, macrophages, and nerve cells- have remained unclear. This review synthesizes current knowledge of how the architecture of the testis unfolds and highlights the questions that remain to be explored, thus providing a roadmap for future studies that may help illuminate the causes of XY disorders of sex development, infertility, and testicular cancers.
Keyword Sex determination
Organogenesis
Sertoli cells
Leydig cells
Disorder of sex development
Fertility
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
 
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