Multiphase flow microfluidics for the production of single or multiple emulsions for drug delivery

Zhao, Chun-Xia (2013) Multiphase flow microfluidics for the production of single or multiple emulsions for drug delivery. Advanced Drug Delivery Reviews, 65 11-12: 1420-1446. doi:10.1016/j.addr.2013.05.009


Author Zhao, Chun-Xia
Title Multiphase flow microfluidics for the production of single or multiple emulsions for drug delivery
Journal name Advanced Drug Delivery Reviews   Check publisher's open access policy
ISSN 0169-409X
1872-8294
Publication date 2013-11-15
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.addr.2013.05.009
Volume 65
Issue 11-12
Start page 1420
End page 1446
Total pages 27
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2014
Language eng
Abstract Considerable effort has been directed towards developing novel drug delivery systems. Microfluidics, capable of generating monodisperse single and multiple emulsion droplets, executing precise control and operations on these droplets, is a powerful tool for fabricating complex systems (microparticles, microcapsules, microgels) with uniform size, narrow size distribution and desired properties, which have great potential in drug delivery applications. This review presents an overview of the state-of-the-art multiphase flow microfluidics for the production of single emulsions or multiple emulsions for drug delivery. The review starts with a brief introduction of the approaches for making single and multiple emulsions, followed by presentation of some potential drug delivery systems (microparticles, microcapsules and microgels) fabricated in microfluidic devices using single or multiple emulsions as templates. The design principles, manufacturing processes and properties of these drug delivery systems are also discussed and compared. Furthermore, drug encapsulation and drug release (including passive and active controlled release) are provided and compared highlighting some key findings and insights. Finally, site-targeting delivery using multiphase flow microfluidics is also briefly introduced.
Keyword Controlled release
Droplet microfluidics
Drug delivery
Microcapsules
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
ERA White List Items
Australian Institute for Bioengineering and Nanotechnology Publications
 
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