Disrupting prefrontal cortex prevents performance gains from sensory-motor training

Filmer, Hannah L., Mattingley, Jason B., Marois, Rene and Dux, Paul E. (2013) Disrupting prefrontal cortex prevents performance gains from sensory-motor training. Journal of Neuroscience, 33 47: 18654-18660. doi:10.1523/JNEUROSCI.2019-13.2013

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Author Filmer, Hannah L.
Mattingley, Jason B.
Marois, Rene
Dux, Paul E.
Title Disrupting prefrontal cortex prevents performance gains from sensory-motor training
Journal name Journal of Neuroscience   Check publisher's open access policy
ISSN 0270-6474
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1523/JNEUROSCI.2019-13.2013
Open Access Status File (Publisher version)
Volume 33
Issue 47
Start page 18654
End page 18660
Total pages 7
Place of publication Washington, DC United States
Publisher Society for Neuroscience
Language eng
Subject 2800 Neuroscience
Abstract Humans show large and reliable performance impairments when required to make more than one simple decision simultaneously. Such multitasking costs are thought to largely reflect capacity limits in response selection (Welford, 1952; Pashler, 1984, 1994), the information processing stage at which sensory input is mapped to a motor response. Neuroimaging has implicated the left posterior lateral prefrontal cortex (pLPFC) as a key neural substrate of response selection (Dux et al., 2006, 2009; Ivanoff et al., 2009). For example, activity in left pLPFC tracks improvements in response selection efficiency typically observed following training (Dux et al., 2009). To date, however, there has been no causal evidence that pLPFC contributes directly to sensory-motor training effects, or the operations through which training occurs. Moreover, the left hemisphere lateralization of this operation remains controversial (Jiang and Kanwisher, 2003; Sigman and Dehaene, 2008; Verbruggen et al., 2010). We used anodal (excitatory), cathodal (inhibitory), and sham transcranial direct current stimulation (tDCS) to left and right pLPFC and measured participants' performance on high and low response selection load tasks after different amounts of training. Both anodal and cathodal stimulation of the left pLPFC disrupted training effects for the high load condition relative to sham. No disruption was found for the low load and right pLPFC stimulation conditions. The findings implicate the left pLPFC in both response selection and training effects. They also suggest that training improves response selection efficiency by fine-tuning activity in pLPFC relating to sensory-motor translations.
Keyword Neurosciences
Neurosciences & Neurology
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID DP110102925
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
School of Psychology Publications
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Citation counts: TR Web of Science Citation Count  Cited 17 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 19 times in Scopus Article | Citations
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Created: Tue, 03 Dec 2013, 10:31:55 EST by System User on behalf of School of Psychology