Transplanted germ cells persist long-term in irradiated ram testes

Stockwell, S., Hill, J. R., Davey, R., Herrid, M. and Lehnert, S. A. (2013) Transplanted germ cells persist long-term in irradiated ram testes. Animal Reproduction Science, 142 3-4: 137-140. doi:10.1016/j.anireprosci.2013.09.012

Author Stockwell, S.
Hill, J. R.
Davey, R.
Herrid, M.
Lehnert, S. A.
Title Transplanted germ cells persist long-term in irradiated ram testes
Journal name Animal Reproduction Science   Check publisher's open access policy
ISSN 0378-4320
Publication date 2013-11-30
Sub-type Article (original research)
DOI 10.1016/j.anireprosci.2013.09.012
Open Access Status Not yet assessed
Volume 142
Issue 3-4
Start page 137
End page 140
Total pages 4
Place of publication Amsterdam, The Netherlands
Publisher Elsevier BV
Language eng
Subject 1103 Clinical Sciences
3403 Food Animals
1310 Endocrinology
Abstract Testicular germ cell transplantation provides a tool to study transgenesis, spermatogenesis and to increase production efficiency in livestock industries. Isolated testicular germ cells can be transplanted into testes of livestock breeds to generate sperm of donor origin. In sheep, methods have been developed previously to isolate cell populations from ram testes and transplant these into irradiated testes of recipient rams. This has resulted in rams producing sperm derived from the donor cells and a number of the recipient animals have produced donor-derived offspring from the introduced spermatogonial cells. Microsatellite genotyping data presented here demonstrates that these rams continue to produce sperm of donor origin for at least 5 years post-transplantation. This research provides new evidence of the stability of transplanted germ cells in a commercially important species, and with further refinements to cell isolation, transplantation and recipient preparation, this technology should find use in breeding systems to increase livestock production efficiency.
Keyword Breeding technologies
Stem cells
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Veterinary Science Publications
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