Health-related quality of life of patients treated with primary chemoradiotherapy for oral cavity squamous cell carcinoma: a comparison with surgery

Crombie, Anthony K., Farah, Camile S. and Batstone, Martin D. (2013) Health-related quality of life of patients treated with primary chemoradiotherapy for oral cavity squamous cell carcinoma: a comparison with surgery. British Journal of Oral and Maxillofacial Surgery, 52 2: 111-117. doi:10.1016/j.bjoms.2013.09.014

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads

Author Crombie, Anthony K.
Farah, Camile S.
Batstone, Martin D.
Title Health-related quality of life of patients treated with primary chemoradiotherapy for oral cavity squamous cell carcinoma: a comparison with surgery
Journal name British Journal of Oral and Maxillofacial Surgery   Check publisher's open access policy
ISSN 0266-4356
1532-1940
Publication date 2013-10-20
Sub-type Article (original research)
DOI 10.1016/j.bjoms.2013.09.014
Open Access Status
Volume 52
Issue 2
Start page 111
End page 117
Total pages 7
Place of publication London, United Kingdom
Publisher Churchill Livingstone
Language eng
Formatted abstract
Our aim was to document the health-related quality of life (QoL) of patients with squamous cell carcinoma (SCC) of the oral cavity who were treated with chemoradiotherapy, and to compare it with that of patients treated with conventional surgery with or without adjuvant treatment. All patients who presented with SCC of the oral cavity treated with chemoradiotherapy alone at the Royal Brisbane & Women's Hospital between 2000 and 2011 and who were alive without disease were included. Health-related QoL was assessed by the University of Washington QoL questionnaire version 4, and the European Organisation for the Research and Treatment of Cancer (EORTC) QoL questionnaires C30 and HN35. The questionnaires were sent to all survivors. Those who responded to chemoradiotherapy were matched with patients who were treated by conventional surgery with or without adjuvant treatment by age, sex, subsite of tumour, and TNM stage. Sixteen patients completed the questionnaires (8 in each group). There was no significant difference between the 2 groups in any of the domains of any of the questionnaires. The overall outcome scores for both treatments in all 3 groups were reasonably high, which suggests that both treatments provided acceptable health-related QoL. The surgical group recorded higher scores than the chemoradiotherapy alone group in all domains of the UW-QoL except shoulder and anxiety. They recorded lower scores in all scales and items of EORTC HN35. There was no significant difference in health-related QoL between the 2 groups. Conventional surgery with or without adjuvant treatment recorded higher scores in most QoL domains including chewing, swallowing, saliva, and speech, issues most important to patients with SCC of the oral cavity.
Keyword Quality of life
Health related quality of life
Oral cancer
Oral squamous cell carcinoma
Head and neck cancer
Chemoradiotherapy
Radiotherapy
Surgery
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 20 October 2013

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 7 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 02 Dec 2013, 22:27:51 EST by Roheen Gill on behalf of School of Dentistry