A retrospective analysis of clinical features of oral malignant and potentially malignant disorders with and without oral epithelial dysplasia

Dost, Fatima, Le Cao, Kim-Anh, Ford, Pauline J. and Farah, Camile S. (2013) A retrospective analysis of clinical features of oral malignant and potentially malignant disorders with and without oral epithelial dysplasia. Oral surgery, oral medicine, oral pathology and oral radiology, 116 6: 725-733. doi:10.1016/j.oooo.2013.08.005


Author Dost, Fatima
Le Cao, Kim-Anh
Ford, Pauline J.
Farah, Camile S.
Title A retrospective analysis of clinical features of oral malignant and potentially malignant disorders with and without oral epithelial dysplasia
Journal name Oral surgery, oral medicine, oral pathology and oral radiology   Check publisher's open access policy
ISSN 2212-4403
2212-4411
Publication date 2013-12-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.oooo.2013.08.005
Open Access Status
Volume 116
Issue 6
Start page 725
End page 733
Total pages 9
Place of publication Amsterdam, The Netherlands
Publisher Elsevier BV
Language eng
Abstract Objective. Clinical identification of underlying histopathology of oral mucosal lesions (OMLs) remains difficult. The study aims to identify clinical indicators of underlying histopathology of oral malignant and potentially malignant disorders. Study Design. All clinical patient records of an oral medicine and pathology clinic over a 12-year period were manually searched. Cases of OMLs with a histopathologic diagnosis of dysplasia (n = 124) and malignancy (n = 27) and a sample of nondysplastic OMLs (n = 109) were analyzed using both univariate and multivariate analysis and odds ratios for an association with clinical characteristics.
Formatted abstract
Objective Clinical identification of underlying histopathology of oral mucosal lesions (OMLs) remains difficult. The study aims to identify clinical indicators of underlying histopathology of oral malignant and potentially malignant disorders.

Study Design All clinical patient records of an oral medicine and pathology clinic over a 12-year period were manually searched. Cases of OMLs with a histopathologic diagnosis of dysplasia (n = 124) and malignancy (n = 27) and a sample of nondysplastic OMLs (n = 109) were analyzed using both univariate and multivariate analysis and odds ratios for an association with clinical characteristics.

Results
A nonhomogeneous clinical appearance was strongly associated with underlying dysplasia in both univariate and multivariate analysis (P <.001; odds ratio, 4.4). For lesions with homogeneous appearance, dysplasia was associated with lesion location (P =.005; odds ratio, 2.6) and smoking history (P =.04).

Conclusions
These findings suggest that a nonhomogeneous mucosal lesion is a significant independent indicator for underlying oral epithelial dysplasia, with location, size, and color as additional contributing factors
Keyword Dentistry
Oral mucosal lesions
Malignant disorders
Oral malignant
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
School of Dentistry Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 02 Dec 2013, 21:39:47 EST by Roheen Gill on behalf of UQ Centre for Clinical Research