Malignant transformation of oral epithelial dysplasia: a real world evaluation of histopathological grading

Dost, F., Le Cao, K., Ford, P. J., Ades, C. and Farah, C. S. (2013) Malignant transformation of oral epithelial dysplasia: a real world evaluation of histopathological grading. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 117 3: 343-352. doi:10.1016/j.oooo.2013.09.017


Author Dost, F.
Le Cao, K.
Ford, P. J.
Ades, C.
Farah, C. S.
Title Malignant transformation of oral epithelial dysplasia: a real world evaluation of histopathological grading
Journal name Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology   Check publisher's open access policy
ISSN 2212-4403
2212-4411
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.oooo.2013.09.017
Open Access Status DOI
Volume 117
Issue 3
Start page 343
End page 352
Total pages 34
Place of publication Amsterdam, The Netherlands
Publisher Elsevier BV
Language eng
Formatted abstract
Objective
This study describes the predictive value of oral epithelial dysplasia (OED) grading as an indicator for malignant transformation and progression.

Study design
The records of an Australian-based pathology laboratory were searched for oral mucosal biopsies with a dysplastic or malignant diagnosis. Examination for an association with progression and malignant transformation without re-interpretation was performed. Analysis was undertaken utilising hazard ratios and Fisher’s exact test.

Results
368 patients with a diagnosis of OED were included. Twenty-six (7.1%) patients underwent progression or malignant transformation; the annual malignant transformation rate was 1%. No other characteristics were associated with a heightened risk of progression or transformation.

Conclusion
The severity of OED, was not associated with risk of malignant transformation, suggesting that the current OED grading system is not useful for predicting patient outcomes or for determining management strategies. Definitive treatment of all OED is recommended, until a more reliable progression/transformation system is developed.
Keyword Oral epithelial dysplasia
Oral squamous cell carcinoma
Malignant transformation
Malignant Progression
Histopathology
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
School of Dentistry Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 02 Dec 2013, 21:28:59 EST by Roheen Gill on behalf of UQ Centre for Clinical Research