Enhanced transcription and translation in clay hydrogel and implications for early life evolution

Yang, Dayong, Peng, Songming, Hartman, Mark R., Gupton-Campolongo, Tiffany, Rice, Edward J., Chang, Anna Kathryn, Gu, Zi, Lu, G. Q. (Max) and Luo, Dan (2013) Enhanced transcription and translation in clay hydrogel and implications for early life evolution. Scientific Reports, 3 3165.1-3165.6. doi:10.1038/srep03165

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Author Yang, Dayong
Peng, Songming
Hartman, Mark R.
Gupton-Campolongo, Tiffany
Rice, Edward J.
Chang, Anna Kathryn
Gu, Zi
Lu, G. Q. (Max)
Luo, Dan
Title Enhanced transcription and translation in clay hydrogel and implications for early life evolution
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2013-11-01
Year available 2013
Sub-type Article (original research)
DOI 10.1038/srep03165
Open Access Status DOI
Volume 3
Start page 3165.1
End page 3165.6
Total pages 6
Place of publication London, United Kingdom
Publisher Nature Publishing
Language eng
Subject 1000 General
2700 Medicine
Abstract In most contemporary life forms, the confinement of cell membranes provides localized concentration and protection for biomolecules, leading to efficient biochemical reactions. Similarly, confinement may have also played an important role for prebiotic compartmentalization in early life evolution when the cell membrane had not yet formed. It remains an open question how biochemical reactions developed without the confinement of cell membranes. Here we mimic the confinement function of cells by creating a hydrogel made from geological clay minerals, which provides an efficient confinement environment for biomolecules. We also show that nucleic acids were concentrated in the clay hydrogel and were protected against nuclease, and that transcription and translation reactions were consistently enhanced. Taken together, our results support the importance of localized concentration and protection of biomolecules in early life evolution, and also implicate a clay hydrogel environment for biochemical reactions during early life evolution.
Keyword Multidisciplinary Sciences
Science & Technology - Other Topics
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID DMR-1120296
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 17 times in Scopus Article | Citations
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