Unravelling the molecular complexity of GPCR-mediated EGFR transactivation using functional genomics approaches

George, Amee J., Hannan, Ross D. and Thomas, Walter G. (2013). Unravelling the molecular complexity of GPCR-mediated EGFR transactivation using functional genomics approaches. In: Special Issue: Frontiers in Cell Signalling, and Ca2+-Signalling and Transport in Health and Disease. The International Symposium ‘Ca2+ Signalling and Transport in Health and Disease’, Aarhus, Denmark, (5258-5268). 19 - 20 June 2012. doi:10.1111/febs.12509


Author George, Amee J.
Hannan, Ross D.
Thomas, Walter G.
Title of paper Unravelling the molecular complexity of GPCR-mediated EGFR transactivation using functional genomics approaches
Conference name The International Symposium ‘Ca2+ Signalling and Transport in Health and Disease’
Conference location Aarhus, Denmark
Conference dates 19 - 20 June 2012
Proceedings title Special Issue: Frontiers in Cell Signalling, and Ca2+-Signalling and Transport in Health and Disease   Check publisher's open access policy
Journal name FEBS Journal   Check publisher's open access policy
Place of Publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing Ltd.
Publication Year 2013
Year available 2013
Sub-type Fully published paper
DOI 10.1111/febs.12509
Open Access Status DOI
ISSN 1742-464X
1742-4658
Volume 280
Issue 21
Start page 5258
End page 5268
Total pages 11
Collection year 2014
Language eng
Abstract/Summary To influence physiology and pathophysiology, G protein-coupled receptors (GPCRs) have evolved to appropriate additional signalling modalities, such as activation of adjacent membrane receptors. Epidermal growth factor receptors (EGFRs) mediate growth and remodelling actions of GPCRs, although the precise network of gene products and molecular cascades linking GPCRs to EGFRs (termed EGFR transactivation) remains incomplete. In this review, we describe the current view of GPCR-EGFR transactivation, identifying the established models of receptor cross-talk. We consider the limitations in our current knowledge, and propose that recent advances in molecular and cell biology technology, including functional genomics approaches, will allow a renewed focus of efforts to understand the mechanism underlying EGFR transactivation. Using an unbiased approach for identification of the molecules required for GPCR-mediated EGFR transactivation will provide a contemporary and more complete representation from which to extrapolate therapeutic control in diseases from cardiovascular remodelling to cancer. Cross-talk between G protein-coupled receptors (GPCRs) and the epidermal growth factor receptor (EGFR) facilitate many important cellular activities. However, the molecular mechanism still remains poorly understood. In this review, we discuss the current view of GPCR-EGFR transactivation, and propose that functional genomics approaches will allow a renewed concentration of our efforts to further investigate the mechanism underlying this process.
Subjects 1303 Specialist Studies in Education
1307 Cell Biology
1312 Molecular Biology
Keyword Cancer
Cardiac hypertrophy
Cardiovascular disease
Epidermal growth factor receptor
Functional Genomics
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Conference Paper
Collections: Official 2014 Collection
School of Biomedical Sciences Publications
 
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