Estrogen-induced cholestasis: Pathogenesis and therapeutic implications

Chen, Jiezhong, Zhao, Kong-Nan and Liu, Guang Bin (2013) Estrogen-induced cholestasis: Pathogenesis and therapeutic implications. Hepato-Gastroenterology, 60 126: 1289-1296. doi:10.5754/hge121061

Author Chen, Jiezhong
Zhao, Kong-Nan
Liu, Guang Bin
Title Estrogen-induced cholestasis: Pathogenesis and therapeutic implications
Journal name Hepato-Gastroenterology   Check publisher's open access policy
ISSN 0172-6390
Publication date 2013-01-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.5754/hge121061
Open Access Status DOI
Volume 60
Issue 126
Start page 1289
End page 1296
Total pages 8
Place of publication Stuttgart, Germany
Publisher Thieme Publishing
Language eng
Subject 2715 Gastroenterology
2721 Hepatology
Abstract Cholestasis syndromes characterised by impairment of bile formation and secretion arecaused by many diseases. Estrogen-induced cholestasis among the cholestasis syndromes is a very common form. Based on the molecular studies of bile formation and transportation, a significant advancement has been achieved in understanding the mechanism of the disease. Estrogen can inhibit bile acids transportation from hepatocytes into bile canaliculi by interfering with the bile salt export pump and multidrug resistance-associated transporter 2 as well. It also inhibits Na+-taurocholate cotransporting polypeptide and Na+-independent organic anion-transporting polypeptides in the basolateral membrane of hepatocytes to interfere with the uptake of bile acids. Thus, co-treatment strategy can be considered which combines nuclear receptor inducers and cAMP enhancer to increase bile acids transporters activities, and the agents to reduce serum estrogen concentration and its receptor binding, and to reduce bile acids in enterohepatic circulation.
Keyword Bile acids
Multidrug resistance-associated transporter
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biomedical Sciences Publications
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