A protocol for the pharmacokinetics of enteric coated mycophenolate sodium in lupus nephritis (POEMSLUN): An open-label, randomised controlled trial

Ranganathan,Dwarakanathan, John, George T., Healy, Helen, Roberts, Matthew J., Fassett, Robert G., Lipman, Jeffrey, Kubler, Paul, Ungerer, Jacobus, McWhinney, Brett C., Lim, Aaron, Purvey, Megan, Reyaldeen, Reza and Roberts, Jason A. (2013) A protocol for the pharmacokinetics of enteric coated mycophenolate sodium in lupus nephritis (POEMSLUN): An open-label, randomised controlled trial. BMJ Open, 3 8: . doi:10.1136/bmjopen-2013-003511

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Author Ranganathan,Dwarakanathan
John, George T.
Healy, Helen
Roberts, Matthew J.
Fassett, Robert G.
Lipman, Jeffrey
Kubler, Paul
Ungerer, Jacobus
McWhinney, Brett C.
Lim, Aaron
Purvey, Megan
Reyaldeen, Reza
Roberts, Jason A.
Title A protocol for the pharmacokinetics of enteric coated mycophenolate sodium in lupus nephritis (POEMSLUN): An open-label, randomised controlled trial
Journal name BMJ Open   Check publisher's open access policy
ISSN 2044-6055
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1136/bmjopen-2013-003511
Open Access Status DOI
Volume 3
Issue 8
Total pages 9
Place of publication London, United Kingdom
Publisher B M J Group
Language eng
Subject 2700 Medicine
Abstract Introduction: Mycophenolate sodium, an enteric-coated tablet (EC-MPS), is as effective and safe as mycophenolate mofetil (MMF) in preventing transplant rejection. EC-MPS and MMF improve the outcome of severe lupus nephritis (LN) and have fewer side effects than pulsed intravenous cyclophosphamide. Blood concentrations of mycophenolic acid (MPA), the active metabolite of EC-MPS, vary between participants despite fixed dosing. Interpatient variability has been studied in transplantation, but not well documented in LN. The relationship between MPA concentration and its clinical effect on LN has not been described.
Keyword Medicine, General & Internal
General & Internal Medicine
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
School of Medicine Publications
 
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Created: Fri, 29 Nov 2013, 06:19:02 EST by System User on behalf of Anaesthesiology and Critical Care - RBWH