Improving the cellular invasion into PHEMA sponges by incorporation of the RGD peptide ligand: The use of copolymerization as a means to functionalize PHEMA sponges

Paterson, Stefan M., Shadforth, Audra M.A., Shaw, Jeremy A., Brown, David H., Chirila, Traian V. and Baker, Murray V. (2013) Improving the cellular invasion into PHEMA sponges by incorporation of the RGD peptide ligand: The use of copolymerization as a means to functionalize PHEMA sponges. Materials Science and Engineering C, 33 8: 4917-4922. doi:10.1016/j.msec.2013.08.011


Author Paterson, Stefan M.
Shadforth, Audra M.A.
Shaw, Jeremy A.
Brown, David H.
Chirila, Traian V.
Baker, Murray V.
Title Improving the cellular invasion into PHEMA sponges by incorporation of the RGD peptide ligand: The use of copolymerization as a means to functionalize PHEMA sponges
Journal name Materials Science and Engineering C   Check publisher's open access policy
ISSN 0928-4931
1873-0191
Publication date 2013-12-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.msec.2013.08.011
Open Access Status
Volume 33
Issue 8
Start page 4917
End page 4922
Total pages 6
Place of publication Lausanne, Switzerland
Publisher Elsevier S.A.
Language eng
Abstract Amonomer that contained the RGD ligandmotifwas synthesized and copolymerized with 2-hydroxyethylmethacrylate using polymerization-induced phase separation methods to form poly(2-hydroxyethyl methacrylate)-based hydrogel sponges. The sponges had morphologies of aggregated polymer droplets and interconnected pores, the pores having dimensions in the order of 10 μm typical of PHEMA sponges. RGD-containing moieties appeared to be evenly distributed through the polymer droplets. Compared to PHEMA sponges that were not functionalizedwith RGD, the new sponges containing RGD allowed greater invasion by human corneal epithelial cells, by advancing the attachment of cells to the surface of the polymer droplets.
Keyword Cell invasion
Peptide ligands
PHEMA
Sponges
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Fri, 29 Nov 2013, 06:14:57 EST by System User on behalf of Aust Institute for Bioengineering & Nanotechnology