Study protocol: The Childhood to Adolescence Transition Study (CATS)

Mundy, Lisa K, Simmons, Julian G, Allen, Nicholas B, Viner, Russell M, Bayer, Jordana K, Olds, Timothy, Williams, Jo, Olsson,Craig, Romaniuk, Helena, Mensah, Fiona, Sawyer, Susan M, Degenhardt,Louisa, Alati, Rosa, Wake, Melissa, Jacka, Felice and Patton, George C (2013) Study protocol: The Childhood to Adolescence Transition Study (CATS). BMC Pediatrics, 13 160: 160.1-160.13. doi:10.1186/1471-2431-13-160

Author Mundy, Lisa K
Simmons, Julian G
Allen, Nicholas B
Viner, Russell M
Bayer, Jordana K
Olds, Timothy
Williams, Jo
Romaniuk, Helena
Mensah, Fiona
Sawyer, Susan M
Alati, Rosa
Wake, Melissa
Jacka, Felice
Patton, George C
Title Study protocol: The Childhood to Adolescence Transition Study (CATS)
Journal name BMC Pediatrics   Check publisher's open access policy
ISSN 1471-2431
Publication date 2013-10-08
Year available 2013
Sub-type Article (original research)
DOI 10.1186/1471-2431-13-160
Open Access Status DOI
Volume 13
Issue 160
Start page 160.1
End page 160.13
Total pages 13
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Formatted abstract
Background: Puberty is a multifaceted developmental process that begins in late-childhood with a cascade of endocrine changes that ultimately lead to sexual maturation and reproductive capability. The transition through puberty is marked by an increased risk for the onset of a range of health problems, particularly those related to the control of behaviour and emotion. Early onset puberty is associated with a greater risk of cancers of the reproductive tract and cardiovascular disease. Previous studies have had methodological limitations and have tended to view puberty as a unitary process, with little distinction between adrenarche, gonadarche and linear growth. The Childhood to Adolescence Transition Study (CATS) aims to prospectively examine associations between the timing and stage of the different hormonally-mediated changes, as well as the onset and course of common health and behavioural problems that emerge in the transition from childhood to adolescence. The initial focus of CATS is on adrenarche, the first hormonal process in the pubertal cascade, which begins for most children at around 8 years of age.

Methods/Design: CATS is a longitudinal population-based cohort study. All Grade 3 students (8-9 years of age) from a stratified cluster sample of schools in Melbourne, Australia were invited to take part. In total, 1239 students and a parent/guardian were recruited to participate in the study. Measures are repeated annually and comprise student, parent and teacher questionnaires, and student anthropometric measurements. A saliva sample was collected from students at baseline and will be repeated at later waves, with the primary purpose of measuring hormonal indices of adrenarche and gonadarche.

Discussion: CATS is uniquely placed to capture biological and phenotypic indices of the pubertal process from its earliest manifestations, together with anthropometric measures and assessment of child health and development. The cohort will provide rich detail of the development, lifestyle, external circumstances and health of children during the transition from childhood through to adolescence. Baseline associations between the hormonal measures and measures of mental health and behaviour will initially be examined cross-sectionally, and then in later waves longitudinally. CATS will make a unique contribution to the understanding of adrenarche and puberty in children's health and development.
Keyword Adolescent
Cohort studies
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Public Health Publications
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