The expression pattern of EVA1C, a novel slit receptor, is consistent with an axon guidance role in the mouse nervous system

James, Gregory, Foster, Simon R., Key, Brian and Beverdam, Annemiek (2013) The expression pattern of EVA1C, a novel slit receptor, is consistent with an axon guidance role in the mouse nervous system. PloS One, 8 9: e74115.1-e74115.10. doi:10.1371/journal.pone.0074115


Author James, Gregory
Foster, Simon R.
Key, Brian
Beverdam, Annemiek
Title The expression pattern of EVA1C, a novel slit receptor, is consistent with an axon guidance role in the mouse nervous system
Journal name PloS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2013-09-09
Year available 2013
Sub-type Article (original research)
DOI 10.1371/journal.pone.0074115
Open Access Status DOI
Volume 8
Issue 9
Start page e74115.1
End page e74115.10
Total pages 10
Editor Juan-Pablo Labrador
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Language eng
Subject 1100 Agricultural and Biological Sciences
1300 Biochemistry, Genetics and Molecular Biology
2700 Medicine
Formatted abstract
The Slit/Robo axon guidance families play a vital role in the formation of neural circuitry within select regions of the developing mouse nervous system. Typically Slits signal through the Robo receptors, however they also have Robo-independent functions. The novel Slit receptor Eva-1, recently discovered in C. elegans, and the human orthologue of which is located in the Down syndrome critical region on chromosome 21, could account for some of these Robo independent functions as well as provide selectivity to Robo-mediated axon responses to Slit. Here we investigate the expression of the mammalian orthologue EVA1C in regions of the developing mouse nervous system which have been shown to exhibit Robo-dependent and -independent responses to Slit. We report that EVA1C is expressed by axons contributing to commissures, tracts and nerve pathways of the developing spinal cord and forebrain. Furthermore it is expressed by axons that display both Robo-dependent and -independent functions of Slit, supporting a role for EVA1C in Slit/Robo mediated neural circuit formation in the developing nervous system.
Keyword Multidisciplinary Sciences
Science & Technology - Other Topics
MULTIDISCIPLINARY SCIENCES
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 631598
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Biomedical Sciences Publications
 
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