Elongate microparticles for enhanced drug delivery to ex vivo and in vivo pig skin

Raphael, Anthony P., Primiero, Clare A., Ansaldo, Alexander B., Keates, Helen L., Soyer, H. Peter and Prow, Tarl W. (2013) Elongate microparticles for enhanced drug delivery to ex vivo and in vivo pig skin. Journal of Controlled Release, 172 1: 96-104. doi:10.1016/j.jconrel.2013.07.025


Author Raphael, Anthony P.
Primiero, Clare A.
Ansaldo, Alexander B.
Keates, Helen L.
Soyer, H. Peter
Prow, Tarl W.
Title Elongate microparticles for enhanced drug delivery to ex vivo and in vivo pig skin
Journal name Journal of Controlled Release   Check publisher's open access policy
ISSN 0168-3659
1873-4995
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.jconrel.2013.07.025
Volume 172
Issue 1
Start page 96
End page 104
Total pages 9
Place of publication Amsterdam, The Netherlands
Publisher Elsevier BV
Language eng
Subject 3003 Pharmaceutical Science
Abstract The delivery of therapeutics and cosmaceuticals into and/or through the skin is hindered by epidermal barriers. To overcome the skin's barriers we have developed a novel cutaneous delivery method using high aspect ratio elongate microparticles (EMPs). Using ex vivo and in vivo pig skin we assess the penetration and delivery characteristics of the elongate microparticles. With reflectance confocal microscopy we observed that the elongate microparticles successfully penetrated the epidermis and upper dermis. Delivery was then assessed using two different length populations of EMPs, comparing their delivery profile to topical alone using sodium fluorescein and confocal microscopy. We observed a relatively uniform and continuous delivery profile in the EMP treated area within the upper layers of the skin - up to seven times greater than topical alone. Finally, we delivered two therapeutically relevant compounds (Vitamins A and B3), showing enhanced delivery using the EMPs. To our knowledge this is the first report using high aspect ratio elongate microparticles in this manner for enhanced topical delivery to the skin.
Keyword Drug delivery
Microneedles
Microparticles
Skin disease
Transdermal delivery
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Author post-print permissible

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
School of Veterinary Science Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 11 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 29 Nov 2013, 05:26:06 EST by System User on behalf of Medicine - Princess Alexandra Hospital