RAGE and TLRs: relatives, friends or neighbours?

Ibrahim, Zaridatul Aini, Armour, Carol L., Phipps, Simon and Sukkar, Maria B. (2013) RAGE and TLRs: relatives, friends or neighbours?. Molecular Immunology, 56 4: 739-744. doi:10.1016/j.molimm.2013.07.008

Author Ibrahim, Zaridatul Aini
Armour, Carol L.
Phipps, Simon
Sukkar, Maria B.
Title RAGE and TLRs: relatives, friends or neighbours?
Journal name Molecular Immunology   Check publisher's open access policy
ISSN 0161-5890
Publication date 2013-12-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.molimm.2013.07.008
Open Access Status Not yet assessed
Volume 56
Issue 4
Start page 739
End page 744
Total pages 6
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon
Language eng
Subject 1312 Molecular Biology
2403 Immunology
Abstract The innate immune system forms the first line of protection against infectious and non-infectious tissue injury. Cells of the innate immune system detect pathogen-associated molecular patterns or endogenous molecules released as a result of tissue injury or inflammation through various innate immune receptors, collectively termed pattern-recognition receptors. Members of the Toll-like receptor (TLR) family of pattern-recognition receptors have well established roles in the host immune response to infection, while the receptor for advanced glycation end products (RAGE) is a pattern-recognition receptor predominantly involved in the recognition of endogenous molecules released in the context of infection, physiological stress or chronic inflammation. RAGE and TLRs share common ligands and signaling pathways, and accumulating evidence points towards their co-operative interaction in the host immune response. At present however, little is known about the mechanisms that result in TLR versus RAGE signalling or RAGE-TLR cross-talk in response to their shared ligands. Here we review what is known in relation to the physicochemical basis of ligand interactions between TLRs and RAGE, focusing on three shared ligands of these receptors: HMGB1, S100A8/A9 and LPS. Our aim is to discuss what is known about differential ligand interactions with RAGE and TLRs and to highlight important areas for further investigation so that we may better understand the role of these receptors and their relationship in host defense.
Keyword High mobility group box-1 (HMGB1)
Lipopolysaccharide (LPS)
Pattern-recognition receptors (PRRs)
Receptor for advanced glycation end products (RAGE)
S100 proteins
Toll-like receptors (TLRs)
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Biomedical Sciences Publications
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