Mechanosensory transduction

Martinac, B. and Kloda, A. (2012). Mechanosensory transduction. In Edward H. Egelman (Ed.), Comprehensive Biophysics (pp. 108-141) Amsterdam, Netherlands: Elsevier. doi:10.1016/B978-0-12-374920-8.00618-4

Author Martinac, B.
Kloda, A.
Title of chapter Mechanosensory transduction
Title of book Comprehensive Biophysics
Place of Publication Amsterdam, Netherlands
Publisher Elsevier
Publication Year 2012
Sub-type Research book chapter (original research)
DOI 10.1016/B978-0-12-374920-8.00618-4
ISBN 9780080957180
Editor Edward H. Egelman
Volume number 6
Start page 108
End page 141
Total pages 34
Language eng
Subjects 1300 Biochemistry, Genetics and Molecular Biology
Formatted Abstract/Summary
This chapter highlights the major progress that has been achieved in studies of mechanosensitive (MS) ion channels from prokaryotic and eukaryotic cells whose molecular identity has been elucidated to date. The first part focuses on mechanotransduction in microbial and plant cells and briefly describes the structure, function, gating mechanism, and pharmacology of two major types of MS channels of large and small conductance that are present in these cells. The second part focuses on diversity of stretch-activated (SA) channels that have been identified to play a role in mechanosensory transduction in animal cells. This part highlights the role of the lipid bilayer and the cytoskeleton as well as interaction of extracellular matrix components with eukaryotic MS ion channels. The chapter also describes mechanosensitivity of cells from various tissues, including nervous system, cochlea, skin skeletal muscle, bone and cartilage, heart and blood vessels. Furthermore, it refers briefly to the role that SA channels may play in the pathology of diseases, including neuronal and cardiovascular pathophysiology.
Keyword Amphipaths
Bilayer model
Fatty acids
Hair cells
Mechanosensitive ion channels
Patch clamp
Tethered model
Q-Index Code B1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Book Chapter
Collection: School of Biomedical Sciences Publications
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