Mechanism of Action of Conventional and Targeted Anticancer Therapies: Reinstating Immunosurveillance

Zitvogel, Laurence, Galluzzi, Lorenzo, Smyth, Mark J. and Kroemer, Guido (2013) Mechanism of Action of Conventional and Targeted Anticancer Therapies: Reinstating Immunosurveillance. Immunity, 39 1: 74-88. doi:10.1016/j.immuni.2013.06.014


Author Zitvogel, Laurence
Galluzzi, Lorenzo
Smyth, Mark J.
Kroemer, Guido
Title Mechanism of Action of Conventional and Targeted Anticancer Therapies: Reinstating Immunosurveillance
Journal name Immunity   Check publisher's open access policy
ISSN 1074-7613
1097-4180
Publication date 2013-07-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.immuni.2013.06.014
Open Access Status DOI
Volume 39
Issue 1
Start page 74
End page 88
Total pages 15
Place of publication Cambridge, United States
Publisher Cell Press
Language eng
Abstract Conventional chemotherapeutics and targeted antineoplastic agents have been developed based on the simplistic notion that cancer constitutes a cell-autonomous genetic or epigenetic disease. However, it is becoming clear that many of the available anticancer drugs that have collectively saved millions of life-years mediate therapeutic effects by eliciting de novo or reactivating pre-existing tumor-specific immune responses. Here, we discuss the capacity of both conventional and targeted anticancer therapies to enhance the immunogenic properties of malignant cells and to stimulate immune effector cells, either directly or by subverting the immunosuppressive circuitries that preclude antitumor immune responses in cancer patients. Accumulating evidence indicates that the therapeutic efficacy of several antineoplastic agents relies on their capacity to influence the tumor-host interaction, tipping the balance toward the activation of an immune response specific for malignant cells. We surmise that the development of successful anticancer therapies will be improved and accelerated by the immunological characterization of candidate agents.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
School of Medicine Publications
 
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