Impact on hemostatic parameters of interrupting sitting with intermittent activity

Howard, Bethany J., Fraser, Steve F., Sethi, Parneet, Cerin, Ester, Hamilton, Marc T., Owen, Neville, Dunstan, David W. and Kingwell, Bronwyn A. (2013) Impact on hemostatic parameters of interrupting sitting with intermittent activity. Medicine and Science in Sports and Exercise, 45 7: 1285-1291. doi:10.1249/MSS.0b013e318285f57e


Author Howard, Bethany J.
Fraser, Steve F.
Sethi, Parneet
Cerin, Ester
Hamilton, Marc T.
Owen, Neville
Dunstan, David W.
Kingwell, Bronwyn A.
Title Impact on hemostatic parameters of interrupting sitting with intermittent activity
Journal name Medicine and Science in Sports and Exercise   Check publisher's open access policy
ISSN 0195-9131
1530-0315
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1249/MSS.0b013e318285f57e
Open Access Status
Volume 45
Issue 7
Start page 1285
End page 1291
Total pages 7
Place of publication Philadelphia, PA United States
Publisher Lippincott Williams & Wilkins
Language eng
Subject 2732 Orthopedics and Sports Medicine
3612 Physical Therapy, Sports Therapy and Rehabilitation
Abstract INTRODUCTION: Excessive sitting has been associated with an elevated risk of vascular conditions, particularly venous thrombosis. Interrupting sitting time with intermittent physical activity can reduce venous stasis; however, impacts on other aspects of thrombogenesis are less understood. PURPOSE: To examine the effects of interrupting sitting time on blood coagulation and blood volume parameters in sedentary, middle-age, overweight/obese adults (11 men and 8 women; age = 53.8 ± 4.9 yr, body mass index = 31.2 ± 4.1 kg·m; mean ± SD). METHODS: The randomized three-period, three-treatment acute crossover trial consisted of uninterrupted sitting and sitting interrupted by 2-min bouts of either light- or moderate-intensity treadmill walking every 20 min. In each trial condition, blood samples were collected at baseline before the consumption of a standardized meal (-2 h) and postintervention (5 h). RESULTS: Plasma fibrinogen increased from baseline with uninterrupted sitting (0.24 g·L-1, 95% confidence interval = 0.13-0.34, P < 0.001). Light-intensity but not moderate-intensity activity breaks attenuated the increase by 0.17 g·L-1 (95% confidence interval = 0.01-0.32, P < 0.05). There were no between-condition differences in prothrombin time, activated partial thromboplastin time, von Willebrand factor, D-dimer, or platelet count. Uninterrupted sitting reduced plasma volume and increased hematocrit, hemoglobin, and red blood cell count; effects attenuated by both light- and moderate-intensity breaks (P < 0.05). White blood cell count increased with uninterrupted sitting and further increased with moderate-intensity breaks. Mean platelet volume increased with moderate-intensity but not light-intensity breaks or uninterrupted sitting. CONCLUSION: Uninterrupted sitting increased fibrinogen and reduced plasma volume, with associated increases in hemoglobin and hematocrit. Activity breaks attenuated these responses, indicative of an ameliorating influence on the procoagulant effects of uninterrupted sitting. Copyright
Keyword Blood volume
Fibrinogen
Physical activity
Sedentary behavior
Venous thrombosis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Public Health Publications
 
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