Local and remote immune-mediated inflammation after mild peripheral nerve compression in rats

Schmid, Annina B., Coppieters, Michel W., Ruitenberg, Marc J. and McLachlan, Elspeth M. (2013) Local and remote immune-mediated inflammation after mild peripheral nerve compression in rats. Journal of Neuropathology and Experimental Neurology, 72 7: 662-680. doi:10.1097/NEN.0b013e318298de5b


Author Schmid, Annina B.
Coppieters, Michel W.
Ruitenberg, Marc J.
McLachlan, Elspeth M.
Title Local and remote immune-mediated inflammation after mild peripheral nerve compression in rats
Journal name Journal of Neuropathology and Experimental Neurology   Check publisher's open access policy
ISSN 0022-3069
1554-6578
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1097/NEN.0b013e318298de5b
Open Access Status DOI
Volume 72
Issue 7
Start page 662
End page 680
Total pages 19
Place of publication Philadelphia, PA United States
Publisher Lippincott Williams and Wilkins
Language eng
Subject 2734 Pathology and Forensic Medicine
2728 Clinical Neurology
2808 Neurology
2804 Cellular and Molecular Neuroscience
Abstract After experimental nerve injuries that extensively disrupt axons, such as chronic constriction injury, immune cells invade the nerve, related dorsal root ganglia (DRGs), and spinal cord, leading to hyperexcitability, raised sensitivity, and pain. Entrapment neuropathies, such as carpal tunnel syndrome, involve minimal axon damage, but patients often report widespread symptoms. To understand the underlying pathology, a tube was placed around the sciatic nerve in 8-week-old rats, leading to progressive mild compression as the animals grew. Immunofluorescence was used to examine myelin and axonal integrity, glia, macrophages, and T lymphocytes in the nerve, L5 DRGs, and spinal cord after 12 weeks. Tubes that did not constrict the nerve when applied caused extensive and ongoing loss of myelin, together with compromise of small-, but not large-, diameter axons. Macrophages and T lymphocytes infiltrated the nerve and DRGs. Activated glia proliferated in DRGs but not in spinal cord. Histologic findings were supported by clinical hyperalgesia to blunt pressure and cold allodynia. Tubes that did not compress the nerve induced only minor local inflammation. Thus, progressive mild nerve compression resulted in chronic local and remote immune-mediated inflammation depending on the degree of compression. Such neuroinflammation may explain the widespread symptoms in patients with entrapment neuropathies.
Keyword Carpal tunnel syndrome
Central mechanisms
Immune system
Inflammation
Nerve compression
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Biomedical Sciences Publications
School of Health and Rehabilitation Sciences Publications
 
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