Toll-like receptors 2 and 4 modulate autonomic control of heart rate and energy metabolism.

Okun, Eitan, Griffioen, Kathleen J., Rothman, Sarah, Wan, Ruiqian, Cong, Wei-Na, De Cabo, Rafael, Martin-Montalvo, Alejandro, Levette, Andrew, Maudsley, Stuart, Martin, Bronwen, Arumugam, Thiruma Valavan and Mattson, Mark P. (2013) Toll-like receptors 2 and 4 modulate autonomic control of heart rate and energy metabolism.. Brain, Behavior and Immunity, 36 90-100. doi:10.1016/j.bbi.2013.10.013

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Author Okun, Eitan
Griffioen, Kathleen J.
Rothman, Sarah
Wan, Ruiqian
Cong, Wei-Na
De Cabo, Rafael
Martin-Montalvo, Alejandro
Levette, Andrew
Maudsley, Stuart
Martin, Bronwen
Arumugam, Thiruma Valavan
Mattson, Mark P.
Title Toll-like receptors 2 and 4 modulate autonomic control of heart rate and energy metabolism.
Journal name Brain, Behavior and Immunity   Check publisher's open access policy
ISSN 0889-1591
1090-2139
Publication date 2013-10-18
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.bbi.2013.10.013
Open Access Status DOI
Volume 36
Start page 90
End page 100
Total pages 11
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Language eng
Formatted abstract
Highlight
• TLR2 and TLR4 signaling influence autonomic regulation of heart rate (HR) body temperature and energy metabolism in mice.

Toll-like receptors (TLR) are innate immune receptors typically activated by microbial-associated molecular patterns (MAMPs) during infection or damage-associated molecular patterns (DAMPs) as a result of tissue injury. Recent findings suggest that TLR2 and TLR4 signaling play important roles in developmental and adult neuroplasticity, and in learning and memory. In addition, activation of TLR2 and TLR4 worsens ischemic injury to the heart and brain in animal models of myocardial infarction and stroke. TLR activation is also implicated in thermoregulation and fever in response to infection. However, it is not known whether TLRs participate in the regulation of the sympathetic and/or parasympathetic components of the autonomic nervous system (ANS). Here we provide evidence that TLR2 and TLR4 influence autonomic regulation of heart rate (HR) body temperature and energy metabolism in mice. We show that mice lacking TLR2 or TLR4 exhibit reduced basal HR, which results from an increase of parasympathetic tone. In addition, thermoregulatory responses to stress are altered in TLR2−/− and TLR4−/− mice, and brown fat-dependent thermoregulation is altered in TLR4−/− mice. Moreover, TLR2−/− and TLR4−/− mice consume less food and exhibit a greater mass compared to wild type mice. Collectively, our findings suggest important roles for TLR2 and TLR4 in the ANS regulation of cardiovascular function, thermoregulation, and energy metabolism.
Keyword Innate immunity
Toll-like receptors
TLR2
TLR4
Autonomic nervous system
ANS
Heart rate
Stress
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 18 October 2013

 
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Created: Fri, 29 Nov 2013, 03:16:02 EST by Dr Thiruma V Arumugam on behalf of School of Biomedical Sciences