Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells

Ma, Yuting, Adjemian, Sandy, Mattarollo, Stephen R., Yamazaki, Takahiro, Aymeric, Laetitia, Yang, Heng, Portela Catani, Joao P., Hannani, Dalil, Duret, Helene, Steegh, Kim, Martins, Isabelle, Schlemmer, Frederic, Michaud, Michael, Kepp, Oliver, Sukkurwala, Abdul Qader, Menger, Laurie, Vacchelli, Erika, Droin, Nathalie, Galluzzi, Lorenzo, Krzysiek, Roman, Gordon, Siamon, Taylor, Philip R., Van Endert, Peter, Solary, Eric, Smyth, Mark J., Zitvogel, Laurence and Kroemer, Guido (2013) Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells. Immunity, 38 4: 729-741. doi:10.1016/j.immuni.2013.03.003

Author Ma, Yuting
Adjemian, Sandy
Mattarollo, Stephen R.
Yamazaki, Takahiro
Aymeric, Laetitia
Yang, Heng
Portela Catani, Joao P.
Hannani, Dalil
Duret, Helene
Steegh, Kim
Martins, Isabelle
Schlemmer, Frederic
Michaud, Michael
Kepp, Oliver
Sukkurwala, Abdul Qader
Menger, Laurie
Vacchelli, Erika
Droin, Nathalie
Galluzzi, Lorenzo
Krzysiek, Roman
Gordon, Siamon
Taylor, Philip R.
Van Endert, Peter
Solary, Eric
Smyth, Mark J.
Zitvogel, Laurence
Kroemer, Guido
Title Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells
Journal name Immunity   Check publisher's open access policy
ISSN 1074-7613
Publication date 2013-04-18
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.immuni.2013.03.003
Open Access Status Not yet assessed
Volume 38
Issue 4
Start page 729
End page 741
Total pages 13
Place of publication Cambridge, MA United States
Publisher Cell Press
Language eng
Subject 2723 Immunology and Allergy
2725 Infectious Diseases
2403 Immunology
Abstract The therapeutic efficacy of anthracyclines relies on antitumor immune responses elicited by dying cancer cells. How chemotherapy-induced cell death leads to efficient antigen presentation to T cells, however, remains a conundrum. We found that intratumoral CD11c+CD11b+Ly6Chi cells, which displayed some characteristics of inflammatory dendritic cells and included granulomonocytic precursors, were crucial for anthracycline-induced anticancer immune responses. ATP released by dying cancer cells recruited myeloid cells into tumors and stimulated the local differentiation of CD11c+CD11b+Ly6Chi cells. Such cells efficiently engulfed tumor antigens in situ and presented them to T lymphocytes, thus vaccinating mice, upon adoptive transfer, against a challenge with cancer cells. Manipulations preventing tumor infiltration by CD11c+CD11b+Ly6Chi cells, such as the local overexpression of ectonucleotidases, the blockade of purinergic receptors, or the neutralization of CD11b, abolished the immune system-dependent antitumor activity of anthracyclines. Our results identify a subset of tumor-infiltrating leukocytes as therapy-relevant antigen-presenting cells.
Keyword Immunology
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
UQ Diamantina Institute Publications
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