Reconstructing analgesic trials: Reasons for following the lead of oncologists

Davis, Mellar P. and Mitchell, Geoffrey (2012) Reconstructing analgesic trials: Reasons for following the lead of oncologists. Current Opinion in Supportive and Palliative Care, 6 4: 490-493. doi:10.1097/SPC.0b013e32835931db


Author Davis, Mellar P.
Mitchell, Geoffrey
Title Reconstructing analgesic trials: Reasons for following the lead of oncologists
Journal name Current Opinion in Supportive and Palliative Care   Check publisher's open access policy
ISSN 1751-4258
1751-4266
Publication date 2012-01-01
Year available 2012
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1097/SPC.0b013e32835931db
Open Access Status Not Open Access
Volume 6
Issue 4
Start page 490
End page 493
Total pages 4
Place of publication London, United Kingdom
Publisher Lippincott Williams and Wilkins, Ltd.
Language eng
Subject 2730 Oncology
2700 Medicine
2706 Critical Care and Intensive Care Medicine
2917 Oncology (nursing)
Abstract Purpose of review Changes in drug trial designs in oncology, which involve targeted therapies and well genotyped cancers have important implications to the present trial designs used for analgesic development. Recent findings Pain phenotypes influence analgesic responses. Analgesics can now be targeted to pain phenotypes. IMMPACT strategies should be modified using pharmacokinetic- pharmacodynamics and phase II-III trial designs commonly used in oncology. Summary Modifying analgesic trial designs will facilitate the development of targeted analgesics and improve the 'signal-to-noise' ratio over present analgesic trial strategies, which are largely based on pain severity and changes in pain intensity over time.
Keyword Pain
Pharmacodynamics
Pharmacokinetics
Phase II-III trials
Phenotype
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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