Delivery of drugs applied topically to the skin

Leite-Silva, Vania Rodrigues, de Almeida, Mariana Mandelli, Fradin, Aurelie, Grice, Jeffrey Ernest and Roberts, Michael Stephen (2012) Delivery of drugs applied topically to the skin. Expert Review of Dermatology, 7 4: 383-397. doi:10.1586/edm.12.32

Author Leite-Silva, Vania Rodrigues
de Almeida, Mariana Mandelli
Fradin, Aurelie
Grice, Jeffrey Ernest
Roberts, Michael Stephen
Title Delivery of drugs applied topically to the skin
Journal name Expert Review of Dermatology   Check publisher's open access policy
ISSN 1746-9872
Publication date 2012-08-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1586/edm.12.32
Open Access Status Not Open Access
Volume 7
Issue 4
Start page 383
End page 397
Total pages 15
Place of publication London, United Kingdom
Publisher Expert Reviews
Subject 2708 Dermatology
Abstract The stratum corneum is a formidable physical, environmental and microbial barrier, protecting mammalian organisms from external insult and maintaining homeostasis. If the skin is to be used as a route of topical drug delivery, the barrier must be overcome, but this can normally only be achieved with small, relatively lipophilic molecules. Strategies to increase the range of substances that are suitable for transdermal delivery and to improve the permeation of particular substances include advanced formulation and the use of chemical and physical enhancement techniques. Nanomaterials are increasingly being exploited as carriers to deliver materials such as drugs, dyes, vaccines or gene fragments to specific cell targets for therapeutic or diagnostic purposes.
Keyword Formulation
Penetration enhancement
Skin barrier
Stratum corneum
Topical application
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
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Citation counts: Scopus Citation Count Cited 9 times in Scopus Article | Citations
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