Synthesis and characterization of poly(amino urea urethane)-based block copolymer and its potential application as injectable pH/temperature-sensitive hydrogel for protein carrier

Huynh, Cong Truc, Nguyen, Quang Vinh, Kang, Seong Woo and Lee, Doo Sung (2012) Synthesis and characterization of poly(amino urea urethane)-based block copolymer and its potential application as injectable pH/temperature-sensitive hydrogel for protein carrier. Polymer (United Kingdom), 53 19: 4069-4075. doi:10.1016/j.polymer.2012.07.031


Author Huynh, Cong Truc
Nguyen, Quang Vinh
Kang, Seong Woo
Lee, Doo Sung
Title Synthesis and characterization of poly(amino urea urethane)-based block copolymer and its potential application as injectable pH/temperature-sensitive hydrogel for protein carrier
Journal name Polymer (United Kingdom)   Check publisher's open access policy
ISSN 0032-3861
1873-2291
Publication date 2012-08-31
Sub-type Article (original research)
DOI 10.1016/j.polymer.2012.07.031
Open Access Status Not Open Access
Volume 53
Issue 19
Start page 4069
End page 4075
Total pages 7
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Formatted abstract
A series of novel block copolymer comprising of poly(ethylene glycol) (PEG) and poly(amino urea urethane) (PAUU) was simply synthesized and characterized. The block copolymers were synthesized by a polyaddition reaction between isocyanate groups of 1,6-diisocyanato hexamethylene with secondary amine and hydroxyl groups of 2-hydroxyethyl piperazine and hydroxyl groups at the ends of PEG in chloroform in the presence of dibutyltin dilaurate as a catalyst and characterized by 1H and 13C NMR, FTIR and gel permeation chromatography. Copolymer aqueous solutions exhibited pH/temperature-dependent sol-gel phase transitions with a sol-to-gel and a gel-to-sol phase transition corresponding to the increasing of pH and temperature, respectively, with low concentrations. The gel regions covered the physiological condition and could be modulated by changing PAUU fraction, molecular weight of PEG and copolymer concentration. The copolymer hydrogel did not show cytotoxicity. After injecting the copolymer solution subcutaneously into SD rats, an in situ gel formed rapidly. The copolymer hydrogel was confirmed as a protein depot carrier; it showed a sustained release of FITC-BSA over 6 weeks. This novel pH/temperature-sensitive hydrogel system is a potential applicable candidate for protein carrier.
Keyword pH/temperature-sensitive hydrogels
Polyurethane
Protein release
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
 
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