Controlling the properties of poly(amino ester urethane)-poly (ethylene glycol)-poly(amino ester urethane) triblock copolymer pH/temperature-sensitive hydrogel

Huynh, Cong Truc and Lee, Doo Sung (2012) Controlling the properties of poly(amino ester urethane)-poly (ethylene glycol)-poly(amino ester urethane) triblock copolymer pH/temperature-sensitive hydrogel. Colloid and Polymer Science, 290 11: 1077-1086. doi:10.1007/s00396-012-2624-z


Author Huynh, Cong Truc
Lee, Doo Sung
Title Controlling the properties of poly(amino ester urethane)-poly (ethylene glycol)-poly(amino ester urethane) triblock copolymer pH/temperature-sensitive hydrogel
Journal name Colloid and Polymer Science   Check publisher's open access policy
ISSN 0303-402X
1435-1536
Publication date 2012-07-01
Sub-type Article (original research)
DOI 10.1007/s00396-012-2624-z
Volume 290
Issue 11
Start page 1077
End page 1086
Total pages 10
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Abstract A series of triblock copolymers composed of poly (ethylene glycol) (PEG) and poly(β-amino ester urethane) (PAEU) was synthesized and characterized. Its aqueous solution can be used as a non-cytotoxic, biodegradable, and pH/temperature-sensitive hydrogel system. The copolymer solutions exhibited sol-to-gel and gel-to-sol transitions with increasing pH and temperature, respectively. The properties of this hydrogel system, such as its sol-gel transition diagram, mechanical properties, and degradation rate, can be controlled by modulating the PEG molecular weight, PAEU block length, copolymer concentration, or structure of the monomers. The presence of urethane groups and ionized tertiary amine groups in the copolymer solution at lightly acidic pH may lead to a strong interaction of the copolymer with formulated bioactive therapeutic agents, while the existence of the gel state under physiological conditions (37 °C, pH 7.4) may enable this copolymer hydrogel to be applicable as a drug/protein carrier.
Keyword Biodegradable
Hydrogels
Ph/temperature-sensitive
Poly (amino ester urethane)
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
 
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