Renal sympathetic denervation for treatment of hypertension

Pimenta, Eduardo and Oparil, Suzanne (2012) Renal sympathetic denervation for treatment of hypertension. Current Treatment Options in Cardiovascular Medicine, 14 2: 127-135. doi:10.1007/s11936-012-0166-9

Author Pimenta, Eduardo
Oparil, Suzanne
Title Renal sympathetic denervation for treatment of hypertension
Journal name Current Treatment Options in Cardiovascular Medicine   Check publisher's open access policy
ISSN 1092-8464
Publication date 2012-04-01
Sub-type Article (original research)
DOI 10.1007/s11936-012-0166-9
Volume 14
Issue 2
Start page 127
End page 135
Total pages 9
Place of publication Philadelphia, United States
Publisher Springer Healthcare
Language eng
Abstract Sympathetic nervous system activation of the heart, kidney and peripheral vasculature increases cardiac output, fluid retention and vascular resistance and plays an important role in acute and chronic BP elevation. Renal sympathetic denervation via a percutaneous radiofrequency catheter based approach is a safe and effective procedure that lowers BP in patients with resistant hypertension. Exploratory studies in patients with resistant hypertension and a variety of comorbidities, including insulin resistance/metabolic syndrome, obstructive sleep apnea and the polycystic ovary syndrome, have shown benefit of renal denervation in attenuating the severity of the comorbid conditions, as well as reducing BP. However, more studies are needed to further address the long term effects of renal denervation and its safety and effectiveness in other disease states such as congestive heart failure.
Keyword Hypertension
Radiofrequency ablation
Renal denervation
Renal nerves
Resistant hypertension
Uncontrolled blood pressure
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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