New biomimetic directions in regenerative ophthalmology

Green, David W., Watson, Gregory S., Watson, Jolanta and Abraham, Samuel J. K. A (2012) New biomimetic directions in regenerative ophthalmology. Advanced Healthcare Materials, 1 2: 140-148. doi:10.1002/adhm.201100039

Author Green, David W.
Watson, Gregory S.
Watson, Jolanta
Abraham, Samuel J. K. A
Title New biomimetic directions in regenerative ophthalmology
Journal name Advanced Healthcare Materials   Check publisher's open access policy
ISSN 2192-2640
Publication date 2012-03-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/adhm.201100039
Open Access Status Not yet assessed
Volume 1
Issue 2
Start page 140
End page 148
Total pages 9
Place of publication Weinheim, Germany
Publisher Wiley
Language eng
Subject 2204 Religion and Religious Studies
2502 Biomaterials
3003 Pharmaceutical Science
Abstract One of the most complete and permanent ways of treating many causes of visual impairment and blindness is to replace the entire affected tissue with pre-cultured ocular tissues supported and maintained on biomaterial frameworks. One direction towards enhancing ocular tissue regeneration on biomaterials, in the laboratory is by applying biomimicry. Specifically to engineer biomaterials with important functional elements of the native extracellular matrices, such as topography, that support and organise cells into coherent tissues. Further problems in regenerative ophthalmology can be potentially solved through application of biomimicry. They include, more efficient ways of moving and transplanting cultivated tissues into correct therapeutic locations inside the eye and scar-less, non-destructive healing of surgical incisions and wounds, to repair structural integrity of tissues at the ocular surface. Two examples are given to show this potential for redeveloping an ocular epithelium onto a nanostructured insect wing surface and producing an origami membrane modelled on deployable structures in nature. Efforts to harness natural innovation will eventually provide unique designs and structures that cannot for now be made synthetically, for regeneration of clinically acceptable ocular tissues.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
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