The offspring of women with severe mental disorder

Morgan, V. A., McGrath, J., Hultman, C. M., Zubrick, S., Bower, C., Croft, M., Valuri, G. and Jablensky, A. V. (2009). The offspring of women with severe mental disorder. In John P. Newnham and Michael G. Ross (Ed.), Early Life Origins of Human Health and Disease (pp. 193-204) Basel, Switzerland: S. Karger. doi:10.1159/000221165


Author Morgan, V. A.
McGrath, J.
Hultman, C. M.
Zubrick, S.
Bower, C.
Croft, M.
Valuri, G.
Jablensky, A. V.
Title of chapter The offspring of women with severe mental disorder
Title of book Early Life Origins of Human Health and Disease
Place of Publication Basel, Switzerland
Publisher S. Karger
Publication Year 2009
Sub-type Research book chapter (original research)
DOI 10.1159/000221165
ISBN 9783805591393
9783805591409
9781283439251
Editor John P. Newnham
Michael G. Ross
Start page 193
End page 204
Total pages 12
Language eng
Subjects 2700 Medicine
Formatted Abstract/Summary
Schizophrenia is a severely disabling disorder with a lifetime risk of about 1%. The aetiology of schizophrenia is complex. Evidence from twin, adoptive and family studies indicates that the disorder involves a significant genetic contribution: children of women with schizophrenia have an 8- to 10-fold higher risk of developing the disorder compared with the general population, with the risk in a monozygotic co-twin increased to about 50-fold. The pattern of inheritance in schizophrenia is not a simple Mendelian one. It is likely that multiple genes of small to moderate effect contribute to the disorder, and that environmental risk factors interact with this genetic susceptibility. However, the precise nature of the genetic and environmental risk factors remains unclear...

The three studies that follow illustrate some of the work currently in progress in the area of neurodevelopment and schizophrenia...
Q-Index Code B1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Book Chapter
Collection: Queensland Brain Institute Publications
 
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