Phase synchrony in the early preterm EEG: Development of methods for estimating synchrony in both oscillations and events

Tokariev, Anton, Palmu, Kirsi, Lano, Aulikki, Metsaranta, Marjo and Vanhatalo, Sampsa (2012) Phase synchrony in the early preterm EEG: Development of methods for estimating synchrony in both oscillations and events. NeuroImage, 60 2: 1562-1573. doi:10.1016/j.neuroimage.2011.12.080


Author Tokariev, Anton
Palmu, Kirsi
Lano, Aulikki
Metsaranta, Marjo
Vanhatalo, Sampsa
Title Phase synchrony in the early preterm EEG: Development of methods for estimating synchrony in both oscillations and events
Journal name NeuroImage   Check publisher's open access policy
ISSN 1053-8119
1095-9572
Publication date 2012-04-02
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2011.12.080
Volume 60
Issue 2
Start page 1562
End page 1573
Total pages 12
Place of publication Amsterdam, The Netherlandsr
Publisher Elsevier BV
Language eng
Subject 2805 Cognitive Neuroscience
2808 Neurology
Abstract Development of neuronal connections relies on proper neuronal activity, and it starts during the time when early preterm babies are treated in the neonatal intensive care units. While synchrony has been a key element in visual assessment of neonatal EEG signals, there has been no unambiguous definitions for synchrony, and no objective measures available for neonatal signals. Estimation of phase locking value (PLV) has been an established paradigm in adults, but many unique characteristics of the neonatal EEG have precluded its applicability in them.In the present paper, we developed the existing PLV-based methods further to be applicable for neonatal signals at two different temporal scales, oscillations and events, where the latter refers technically to quantitating phase synchrony (PS) between band-specific amplitude envelopes (bafPS). In addition, we present a measure for quantitation based on assessing cumulative proportion of time with statistically significant synchrony between the given signal pair.The paper uses real EEG examples and the prior neurobiological knowledge in the process of defining optimal parameters in each step of the procedure. Finally, we apply the method to a set of dense array EEG recordings from very early preterm babies, recorded at conceptional age of less than 30. weeks. By comparing PS and bafPS from babies without and with major cerebrovascular lesion, we show that the effects of brain lesions may be selective both in space and in frequency. These findings do by nature escape visual detection in the conventional EEG reading, however they have intriguing correlates in the current concept of how somatosensory networks are thought to develop and/or become disorganized in the early preterm babies.
Keyword Connectivity
Neonatal neurophysiology
Newborn
Preterm EEG
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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