Replication of the Frank-Starling response in a mock circulation loop

Gregory, Shaun D., Stevens, Michael, Timms, Daniel and Pearcy, Mark (2011). Replication of the Frank-Starling response in a mock circulation loop. In: 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS 2011). EMBS 2011: 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Boston, MA, USA, (6825-6828). 30 August-3 September, 2011. doi:10.1109/IEMBS.2011.6091683


Author Gregory, Shaun D.
Stevens, Michael
Timms, Daniel
Pearcy, Mark
Title of paper Replication of the Frank-Starling response in a mock circulation loop
Conference name EMBS 2011: 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Conference location Boston, MA, USA
Conference dates 30 August-3 September, 2011
Proceedings title 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS 2011)   Check publisher's open access policy
Journal name IEEE Engineering in Medicine and Biology Society. Conference Proceedings   Check publisher's open access policy
Series Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Place of Publication Piscataway, NJ, United States
Publisher Institute of Electrical and Electronics Engineers
Publication Year 2011
Sub-type Fully published paper
DOI 10.1109/IEMBS.2011.6091683
Open Access Status Not yet assessed
ISBN 9781424441211
9781424441228
ISSN 1557-170X
Start page 6825
End page 6828
Total pages 4
Language eng
Abstract/Summary Mock circulation loops (MCLs) are used to evaluate cardiovascular devices prior to in-vivo trials; however they lack the vital autoregulatory responses that occur in humans. This study aimed to develop and implement a left and right ventricular Frank-Starling response in a MCL. A proportional controller based on ventricular end diastolic volume was used to control the driving pressure of the MCL's pneumatically operated ventricles. Ventricular pressure-volume loops and end systolic pressure-volume relationships were produced for a variety of healthy and pathological conditions and compared with human data to validate the simulated Frank-Starling response. The non-linear Frank-Starling response produced in this study successfully altered left and right ventricular contractility with changing preload and was validated with previously reported data. This improvement to an already detailed MCL has resulted in a test rig capable of further refining cardiovascular devices and reducing the number of in-vivo trials.
Formatted Abstract/Summary
Mock circulation loops (MCLs) are used to evaluate cardiovascular devices prior to in-vivo trials; however they lack the vital autoregulatory responses that occur in humans. This study aimed to develop and implement a left and right ventricular Frank-Starling response in a MCL. A proportional controller based on ventricular end diastolic volume was used to control the driving pressure of the MCL's pneumatically operated ventricles. Ventricular pressure-volume loops and end systolic pressure-volume relationships were produced for a variety of healthy and pathological conditions and compared with human data to validate the simulated Frank-Starling response. The non-linear Frank-Starling response produced in this study successfully altered left and right ventricular contractility with changing preload and was validated with previously reported data. This improvement to an already detailed MCL has resulted in a test rig capable of further refining cardiovascular devices and reducing the number of in-vivo trials.
Subjects 1707 Computer Vision and Pattern Recognition
1711 Signal Processing
2204 Religion and Religious Studies
2718 Health Informatics
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Conference Paper
Sub-type: Fully published paper
Collection: School of Medicine Publications
 
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