CD43 regulates the threshold for T cell activation by targeting Cbl functions

Pedraza-Alva, Gustavo, Mérida, Lilia B., del Rio, Roxana, Fierro, Nora A., Cruz-Muñoz, Mario E., Olivares, Norma, Melchy, Erika, Igras, Vivian, Holländer, Georg A., Burakoff, Steven J. and Rosenstein, Yvonne (2011). CD43 regulates the threshold for T cell activation by targeting Cbl functions. In: Fernando López-Casillas and José Vázquez-Prado, Special Issue: 13th IUBMB Conference, 1st PABMB Conference and 3rd Meeting of the Signal Transduction and Oxidative Stress Branches of Sociedad Mexicana de Bioquímica. Proceedings. Cell Signaling Networks 2011: 13th IUBMB Conference, 1st PABMB Conference and 3rd Meeting of the Signal Transduction & Oxidative Stress Branches of SMB, Mérida, Yucatán, México, (940-948). 22–27 October, 2011. doi:10.1002/iub.554


Author Pedraza-Alva, Gustavo
Mérida, Lilia B.
del Rio, Roxana
Fierro, Nora A.
Cruz-Muñoz, Mario E.
Olivares, Norma
Melchy, Erika
Igras, Vivian
Holländer, Georg A.
Burakoff, Steven J.
Rosenstein, Yvonne
Title of paper CD43 regulates the threshold for T cell activation by targeting Cbl functions
Conference name Cell Signaling Networks 2011: 13th IUBMB Conference, 1st PABMB Conference and 3rd Meeting of the Signal Transduction & Oxidative Stress Branches of SMB
Conference location Mérida, Yucatán, México
Conference dates 22–27 October, 2011
Proceedings title Special Issue: 13th IUBMB Conference, 1st PABMB Conference and 3rd Meeting of the Signal Transduction and Oxidative Stress Branches of Sociedad Mexicana de Bioquímica. Proceedings   Check publisher's open access policy
Journal name IUBMB Life   Check publisher's open access policy
Place of Publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Publication Year 2011
Sub-type Fully published paper
DOI 10.1002/iub.554
ISSN 1521-6543
1521-6551
Editor Fernando López-Casillas
José Vázquez-Prado
Volume 63
Issue 10
Start page 940
End page 948
Total pages 9
Language eng
Formatted Abstract/Summary
T cell (TC) activation requires the coordinated signaling of the T cell receptor (TCR) and coreceptor molecules, allowing TCs to respond to lower degrees of TCR occupancy. Coreceptor molecules set the threshold for TC activation by controlling different regulatory signaling loops. The Cbl family members prevent undesired activation of T cells by regulating TCR signals. In this report, we show that TC prestimulation by the CD43 coreceptor molecule before TCR engagement inhibits TCR-dependent c-Cbl tyrosine phosphorylation, c-Cbl interaction with the adapter molecule Crk-L and promotes Cbl-b degradation in a PKCθ-dependent manner. Consequently, the prolonged tyrosine phosphorylation and delayed degradation of ZAP-70 and of the ζ chain lead to enhanced mitogen-activated protein kinase activation and robust TC response. These data indicates that CD43-mediated signals lower the threshold for TC activation by restricting the c-Cbl and Cbl-b inhibitory effects on TCR signaling. In addition to the strength and duration of intracellular signals, our data underscore temporality with which certain molecules are engaged as yet another mechanism to fine tune TC signal quality, and ultimately immune function.
Subjects 1303 Specialist Studies in Education
1307 Cell Biology
1308 Clinical Biochemistry
1312 Molecular Biology
1311 Genetics
Keyword T cell activation
CD43
Cbl
PKCθ
PKC-theta
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Conference Paper
Collection: UQ Diamantina Institute Publications
 
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