Hepatitis B genotypes: Role of testing in clinical practice

Graham Cooksley, W. (2011) Hepatitis B genotypes: Role of testing in clinical practice. Current Hepatitis Reports, 10 2: 79-86. doi:10.1007/s11901-011-0097-z

Author Graham Cooksley, W.
Title Hepatitis B genotypes: Role of testing in clinical practice
Journal name Current Hepatitis Reports   Check publisher's open access policy
ISSN 1540-3416
Publication date 2011-01-01
Year available 2011
Sub-type Article (original research)
DOI 10.1007/s11901-011-0097-z
Open Access Status Not Open Access
Volume 10
Issue 2
Start page 79
End page 86
Total pages 8
Place of publication Philadelphia, PA United States
Publisher Springer Healthcare
Language eng
Subject 2721 Hepatology
2406 Virology
Abstract Hepatitis B viral genotypes influence natural history, with genotype C more likely to develop hepatocellular carcinoma than genotype B, thus influencing the need for intervention. In hepatitis B early antigen (HBeAg)-positive disease, the data with conventional interferon and pegylated interferon (peginterferon) provide compelling evidence that genotype A responds best. The argument for differentiating between genotypes B and C is less clear, but the response in genotype B appears better than in C. Loss of hepatitis B surface antigen (HBsAg) is also most common in genotype A. Patients with genotype A and B should be offered peginterferon as first-line therapy, because it offers potential for HBeAg seroconversion with a finite course of therapy. In HBeAg-negative disease, genotype A again gives the best response, although it is an uncommon genotype here. The response in other genotypes is also good, with 12% of patients losing HBsAg 5 years after treatment. Genotypes may also influence nucleoside resistance mutations and HBsAg loss.
Keyword Cirrhosis
Hepatitis B viral genotypes
Hepatocellular carcinoma
Nucleoside analogs
Occult hepatitis B
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Discipline of General Practice Publications
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