Development, characterization and in vitro assessement of stearylamine-based lipid nanoparticles of paclitaxel

Pandita, D., Ahuja, A., Lather, V., Dutta, T., Velpandian, T. and Khar, R. K. (2011) Development, characterization and in vitro assessement of stearylamine-based lipid nanoparticles of paclitaxel. Die Pharmazie, 66 3: 171-177. doi:10.1691/ph.2011.0274


Author Pandita, D.
Ahuja, A.
Lather, V.
Dutta, T.
Velpandian, T.
Khar, R. K.
Title Development, characterization and in vitro assessement of stearylamine-based lipid nanoparticles of paclitaxel
Formatted title
Development, characterization and in vitro assessement of stearylamine-based lipid nanoparticles of paclitaxel
Journal name Die Pharmazie   Check publisher's open access policy
ISSN 0031-7144
Publication date 2011-03-01
Sub-type Article (original research)
DOI 10.1691/ph.2011.0274
Open Access Status DOI
Volume 66
Issue 3
Start page 171
End page 177
Total pages 7
Place of publication Eschborn, Germany
Publisher Govi Verlag Pharmazeutischer Verlag
Language eng
Subject 3003 Pharmaceutical Science
Formatted abstract
The objective of the study was to design and evaluate a solid lipid nanoparticle (SLN) drug delivery system for delivery of paclitaxel. Components of the SLN were lipid (stearylamine) and surfactants (Pluronic F68 and Soya lecithin). The paclitaxel loaded nanoparticles were prepared by a modified solvent injection method. Experiments were carried out with excipients, where surfactants, lipid and drug molar ratios were varied to optimize the formulation characteristics. The in vitro drug release profile from the nanoparticles followed a diffusion controlled mechanism. The modified solvent injection method ensured high entrapment efficiency (~75%), produced smaller, stable nanoparticles with a narrow size distribution and proved to be a reproducible and fast production method. The present study describes the feasibility and suitability of stearylamine based SLN produced using a mixture of surfactants to develop a clinically useful system with targeting potential for poorly soluble antineoplastic drugs.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 28 Nov 2013, 06:27:26 EST by System User on behalf of UQ Diamantina Institute