The naturally attenuated Kunjin strain of West Nile virus shows enhanced sensitivity to the host type I interferon response

Daffis, Stephane, Lazear, Helen M., Liu, Wen Jun, Audsley, Michelle, Engle, Michael, Khromykh, Alexander A. and Diamond, Michael S. (2011) The naturally attenuated Kunjin strain of West Nile virus shows enhanced sensitivity to the host type I interferon response. Journal of Virology, 85 11: 5664-5668. doi:10.1128/JVI.00232-11


Author Daffis, Stephane
Lazear, Helen M.
Liu, Wen Jun
Audsley, Michelle
Engle, Michael
Khromykh, Alexander A.
Diamond, Michael S.
Title The naturally attenuated Kunjin strain of West Nile virus shows enhanced sensitivity to the host type I interferon response
Journal name Journal of Virology   Check publisher's open access policy
ISSN 0022-538X
1070-6321
Publication date 2011-06-01
Year available 2011
Sub-type Article (original research)
DOI 10.1128/JVI.00232-11
Open Access Status DOI
Volume 85
Issue 11
Start page 5664
End page 5668
Total pages 5
Place of publication Washington, DC United States
Publisher American Society for Microbiology
Language eng
Subject 2403 Immunology
2406 Virology
Abstract The host determinants that contribute to attenuation of the naturally occurring nonpathogenic strain of West Nile virus (WNV), the Kunjin strain (WNVKUN), remain unknown. Here, we show that compared to a highly pathogenic North American strain, WNVKUN exhibited an enhanced sensitivity to the antiviral effects of type I interferon. Our studies establish that the virulence of WNVKUN can be restored in cells and mice deficient in specific interferon regulatory factors (IRFs) or the common type I interferon receptor. Thus, WNVKUN is attenuated primarily through its enhanced restriction by type I interferon- and IRF-3-dependent mechanisms.
Keyword Virology
Virology
VIROLOGY
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID U19 AI083019
511129
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
 
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