Antiangiogenic properties of Koetjapic acid, a natural triterpene isolated from Sandoricum koetjaoe Merr

Nassar, Zeyad D., Aisha, Abdalrahim F. A., Ahamed, Mohamed B. K., Ismail, Zhari, Abu-Salah, Khalid M., Alrokayan, Salman A. and Abdul Majid, Amin Malik Shah (2011) Antiangiogenic properties of Koetjapic acid, a natural triterpene isolated from Sandoricum koetjaoe Merr. Cancer Cell International, 11 . doi:10.1186/1475-2867-11-12


Author Nassar, Zeyad D.
Aisha, Abdalrahim F. A.
Ahamed, Mohamed B. K.
Ismail, Zhari
Abu-Salah, Khalid M.
Alrokayan, Salman A.
Abdul Majid, Amin Malik Shah
Title Antiangiogenic properties of Koetjapic acid, a natural triterpene isolated from Sandoricum koetjaoe Merr
Formatted title
Antiangiogenic properties of Koetjapic acid, a natural triterpene isolated from Sandoricum koetjaoe Merr
Journal name Cancer Cell International   Check publisher's open access policy
ISSN 1475-2867
Publication date 2011-04-27
Sub-type Article (original research)
DOI 10.1186/1475-2867-11-12
Open Access Status DOI
Volume 11
Total pages 8
Place of publication London, United Kingdom
Publisher BioMed
Language eng
Formatted abstract
Background
Angiogenesis, the formation of new blood vessels, has become an important target in cancer therapy. Angiogenesis plays an important role in tumor growth and metastasis. Koetjapic acid (KA) is a seco-A-ring oleanene triterpene isolated from S. koetjape. The solvent extract of this plant species was shown previously to have strong antiangiogenic activity; however the active ingredient(s) that conferred the biological activity and the mode of action was not established. Given the high concentration of KA in S. koetjape, an attempt has been made in this study to investigate the antiangiogenic properties of KA.

Results
Treatment with 10-50 μg/ml KA resulted in dose dependent inhibition of new blood vessels growth in ex vivo rat aortic ring assay. KA was found to be non-cytotoxic against HUVECs with IC50 40.97 ± 0.37 μg/ml. KA inhibited major angiogenesis process steps, endothelial cell migration and differentiation as well as VEGF expression.

Conclusions
The non-cytotoxic compound, KA, may be a potent antiangiogenic agent; its activity may be attributed to inhibition of endothelial cells migration and differentiation as well VEGF suppression.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Article number 12

Document type: Journal Article
Sub-type: Article (original research)
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
 
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