Body mass index in early adulthood and endometrial cancer risk for mismatch repair gene mutation carriers

Win, Aung Ko, Dowty, James G., Antill, Yoland C., English, Dallas R., Baron, John A., Young, Joanne P., Giles, Graham G., Southey, Melissa C., Winship, Ingrid, Lipton, Lara, Parry, Susan, Thibodeau, Stephen N., Haile, Robert W., Gallinger, Steven, Le Marchand, Loïc, Lindor, Noralane M., Newcomb, Polly A., Hopper, John L. and Jenkins, Mark A. (2011) Body mass index in early adulthood and endometrial cancer risk for mismatch repair gene mutation carriers. Obstetrics and Gynecology, 117 4: 899-905. doi:10.1097/AOG.0b013e3182110ea3


Author Win, Aung Ko
Dowty, James G.
Antill, Yoland C.
English, Dallas R.
Baron, John A.
Young, Joanne P.
Giles, Graham G.
Southey, Melissa C.
Winship, Ingrid
Lipton, Lara
Parry, Susan
Thibodeau, Stephen N.
Haile, Robert W.
Gallinger, Steven
Le Marchand, Loïc
Lindor, Noralane M.
Newcomb, Polly A.
Hopper, John L.
Jenkins, Mark A.
Title Body mass index in early adulthood and endometrial cancer risk for mismatch repair gene mutation carriers
Journal name Obstetrics and Gynecology   Check publisher's open access policy
ISSN 0029-7844
1873-233X
Publication date 2011-01-01
Sub-type Article (original research)
DOI 10.1097/AOG.0b013e3182110ea3
Open Access Status Not Open Access
Volume 117
Issue 4
Start page 899
End page 905
Total pages 7
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Language eng
Subject 2729 Obstetrics and Gynaecology
Formatted abstract
Objective: To investigate the association of body mass index (BMI) in early adulthood and endometrial cancer risk for carriers of a germline mutation in a DNA mismatch repair gene.

Methods: We estimated the association between BMI at age 18-20 years and endometrial cancer risk for mismatch repair gene mutation carriers and, as a comparison group, noncarriers using 601 female carriers of a germline mutation in a mismatch repair gene (245 MLH1, 299 MSH2, 38 MSH6, and 19 PMS2) and 533 female noncarriers from the Colon Cancer Family Registry using a weighted Cox proportional hazards regression.

Results: During 51,693 person-years of observation, we observed diagnoses of endometrial cancer for 126 carriers and eight noncarriers. For carriers, there was no evidence of an association between BMI at age 20 years and endometrial cancer (adjusted hazard ratio 0.73 per 5 kg/m2; 95% confidence interval [CI], 0.40-1.34; P=.31). For noncarriers, endometrial cancer risk increased by 74% for each 5-kg/m2 increment in BMI (adjusted hazard ratio 1.74; 95% CI 1.27-2.37; P<.001). The hazard ratio for BMI and endometrial cancer for noncarriers was greater than for carriers (P=.04).

Conclusion: The effect of body mass on endometrial cancer risk depends on the woman's mismatch repair gene mutation carrier status, suggesting obesity-independent endometrial carcinogenesis for carriers.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 17 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 28 Nov 2013, 05:10:31 EST by System User on behalf of School of Medicine