Association of a Notch 3 gene polymorphism with migraine susceptibility

Menon, S., Cox, H. C., Kuwahata, M., Quinlan, S., MacMillan, J. C., Haupt, L. M., Lea, R. A. and Griffiths, L. R. (2011) Association of a Notch 3 gene polymorphism with migraine susceptibility. Cephalalgia, 31 3: 264-270. doi:10.1177/0333102410381143


Author Menon, S.
Cox, H. C.
Kuwahata, M.
Quinlan, S.
MacMillan, J. C.
Haupt, L. M.
Lea, R. A.
Griffiths, L. R.
Title Association of a Notch 3 gene polymorphism with migraine susceptibility
Journal name Cephalalgia   Check publisher's open access policy
ISSN 0333-1024
1468-2982
Publication date 2011-02-01
Sub-type Article (original research)
DOI 10.1177/0333102410381143
Open Access Status Not Open Access
Volume 31
Issue 3
Start page 264
End page 270
Total pages 7
Place of publication London, United Kingdom
Publisher Sage Publications
Language eng
Subject 2728 Clinical Neurology
Formatted abstract
Introduction: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL) shares common symptoms with migraine. Most CADASIL causative mutations occur in exons 3 and 4 of the Notch 3 gene. This study investigated the role of C381T (rs 3815188) and G684A (rs 1043994) single nucleotide polymorphisms (SNP) in exons 3 and 4, respectively, of the Notch 3 gene in migraine.

Results: The first part of the study, in a population of 275 migraineurs and 275 control individuals, found a significant association between the C381T variant and migraine, specifically in migraine without aura (MO) sufferers. The G684A variant was also found to be significantly associated with migraine, specifically in migraine with aura (MA) sufferers. A follow-up study in 300 migraineurs and 300 control individuals did not show replicated association of the C381T variant with migraineurs. However, the G684A variant was again shown to be significantly associated with migraine, specifically with MA.

Conclusion: Further investigation of the G684A variant and the Notch 3 gene is warranted to understand their role in migraine.
Keyword Migraine
CADASIL
Notch 3
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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