Dark adaptation in vitamin A-deficient adults awaiting liver transplantation: improvement with intramuscular vitamin A treatment

Abbott-Johnson, Winsome J., Kerlin, Paul, Abiad, Ghassan, Clague, Alan E. and Cuneo, Ross C. (2011) Dark adaptation in vitamin A-deficient adults awaiting liver transplantation: improvement with intramuscular vitamin A treatment. British Journal of Ophthalmology, 95 4: 544-548. doi:10.1136/bjo.2009.179176


Author Abbott-Johnson, Winsome J.
Kerlin, Paul
Abiad, Ghassan
Clague, Alan E.
Cuneo, Ross C.
Title Dark adaptation in vitamin A-deficient adults awaiting liver transplantation: improvement with intramuscular vitamin A treatment
Journal name British Journal of Ophthalmology   Check publisher's open access policy
ISSN 0007-1161
1468-2079
Publication date 2011-04-01
Year available 2010
Sub-type Article (original research)
DOI 10.1136/bjo.2009.179176
Volume 95
Issue 4
Start page 544
End page 548
Total pages 5
Place of publication London, United Kingdom
Publisher B M J Group
Language eng
Subject 2731 Ophthalmology
2809 Sensory Systems
2804 Cellular and Molecular Neuroscience
Formatted abstract
Background/aims Although vitamin A deficiency is common in chronic liver disease, limited data exist on impairment of dark adaptation and response to therapy. The aims were (1) to assess dark adaptation in patients, (2) to assess the relationship between dark adaptation and vitamin A status, zinc and Child–Pugh score, (3) to compare perceived and measured dark adaptation and (4) to assess the dark adaptation response to intramuscular vitamin A.

Methods This was a prospective study of 20 patients (alcoholic liver disease 10, other parenchymal diseases six, cholestatic diseases four) awaiting liver transplantation. Selection was based on low serum retinol. There were 15 age-matched controls. Dark adaptation was measured with a SST-1 dark adaptometer and perception by questionnaire. Eight patients received 50 000 IU of retinyl palmitate, and dark adaptation was repeated at 1 month.

Results Forty per cent of patients had impaired dark adaptation. Patients with alcoholic liver disease were more impaired than those with other parenchymal diseases (p=0.015). No relationship was found between dark adaptation and the biochemical indicators or Child–Pugh score. Seventy-five per cent of patients with impairment did not perceive a problem. After intervention, light of half the previous intensity could be seen (p=0.05).

Conclusions Dark-adaptation impairment was common, was worse in alcoholic liver disease, was largely not appreciated by the patients and improved with vitamin A treatment.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Published Online First 7 August 2010.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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