Influence of ethylenediaminetetraacetic acid on the active chlorine content of sodium hypochlorite solutions when mixed in various proportions

Clarkson, Roger M., Podlich , Heather M. and Moule, Alex J. (2011) Influence of ethylenediaminetetraacetic acid on the active chlorine content of sodium hypochlorite solutions when mixed in various proportions. Journal of Endodontics, 37 4: 538-543. doi:10.1016/j.joen.2011.01.018


Author Clarkson, Roger M.
Podlich , Heather M.
Moule, Alex J.
Title Influence of ethylenediaminetetraacetic acid on the active chlorine content of sodium hypochlorite solutions when mixed in various proportions
Journal name Journal of Endodontics   Check publisher's open access policy
ISSN 0099-2399
1878-3554
Publication date 2011-04-01
Year available 2011
Sub-type Article (original research)
DOI 10.1016/j.joen.2011.01.018
Open Access Status Not Open Access
Volume 37
Issue 4
Start page 538
End page 543
Total pages 6
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Formatted abstract
Introduction: This study documented the time-related effect on active chlorine content of NaOCl solutions of different concentrations after dilution with ethylenediaminetetraacetic acid (EDTA) in various proportions.
Methods: Five NaOCl solutions (Milton, Black and Gold domestic bleach, and the surfactant containing products, White King and Hypochlor 1% and 4% forte) were mixed with EDTA in the following proportions: 90:10, 75:25, and 50:50. Changes in active chlorine content were determined at intervals between 5 and 18 minutes.
Results: Results were analyzed statistically by using general linear statistical models in SPSS. With the exception of White King solutions, EDTA substantially and rapidly reduced available chlorine even in small proportions, with loss being extreme at first and then more gradual. The reaction was exothermic. Results showed that White King mixed 90:10 lost on average only 8% of its active chlorine at its first measurement (approximately 5 minutes) but lost 36% of its active chlorine when mixed 75:25. The Hypochlor products at 90:10 dilution lost on average 27%-31% active chlorine during this time period. Mixing EDTA with NaOCl caused a dramatic loss of active chlorine for all solutions mixed 50:50. NaOCl solutions containing surfactant had less active chlorine loss for the 75:25 and 90:10 admixtures.
Conclusions: NaOCl and EDTA should not be present in the root canal at the same time if the therapeutic benefits of NaOCl are to be realized, but the order in which they should be used for endodontic irrigation remains a matter of debate.
Keyword Active chlorine content
EDTA
Endodontic irrigation
Sodium hypochlorite
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Dentistry Publications
 
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