Mucin dynamics and enteric pathogens

McGuckin, Michael A., Linden, Sara K., Sutton, Philip and Florin, Timothy H. (2011) Mucin dynamics and enteric pathogens. Nature Reviews Microbiology, 9 4: 265-278. doi:10.1038/nrmicro2538

Author McGuckin, Michael A.
Linden, Sara K.
Sutton, Philip
Florin, Timothy H.
Title Mucin dynamics and enteric pathogens
Journal name Nature Reviews Microbiology   Check publisher's open access policy
ISSN 1740-1526
Publication date 2011-01-01
Year available 2011
Sub-type Article (original research)
DOI 10.1038/nrmicro2538
Open Access Status Not yet assessed
Volume 9
Issue 4
Start page 265
End page 278
Total pages 14
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Subject 2400 Immunology and Microbiology
Abstract The extracellular secreted mucus and the cell surface glycocalyx prevent infection by the vast numbers of microorganisms that live in the healthy gut. Mucin glycoproteins are the major component of these barriers. In this Review, we describe the components of the secreted and cell surface mucosal barriers and the evidence that they form an effective barricade against potential pathogens. However, successful enteric pathogens have evolved strategies to circumvent these barriers. We discuss the interactions between enteric pathogens and mucins, and the mechanisms that these pathogens use to disrupt and avoid mucosal barriers. In addition, we describe dynamic alterations in the mucin barrier that are driven by host innate and adaptive immune responses to infection.
Keyword Microbiology
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 543704
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 430 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 476 times in Scopus Article | Citations
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